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BPI Virtual Presentation: Using High-Throughput Microbioreactors to Fit Raman Spectroscopy Model for Measuring Key Metabolites in Monoclonal Antibody Cell Culture Manufacturing Process

September 22 @ 12:50 am - 1:50 pm EDT

Raman spectroscopy is a process analytical technology for simultaneous in-line measurement of important process outputs in therapeutic protein production via mammalian cell culture, such as concentrations of key metabolites or even the protein being expressed. However, due to the complex and shifting nature of the various chemical species present in the cell culture system, Raman models will likely need to be at least partially trained on a process-specific basis. They must also be robust enough to maintain accuracy throughout the expected manufacturing process operational ranges.
This presentation is a proof-of-concept study to demonstrate a reliable Raman model can be developed in parallel with standard process development experimentation for later deployment in a scaled-up manufacturing process.