Solution Alert

While I have not had first-hand experience with the product yet, there is an electromagnetic flowmeter that features a disposable flow tube designed specifically for single use bioprocessing applications. The flowmeter is manufactured by the German firm Krohne, whose other products for flow and level measurement I have had success with over the years. Here is a link to more information;

Flexmag 4050

To be honest, I was not aware that this was a bioprocess challenge needing to be addressed. However, I did a bit of research and found that the use of "pulsation dampeners" has been explored in bioprocess applications downstream, specifically TFF and Chromatography. As the name implies their purpose is to mitigate the possible adverse effects of pressure and flow pulsations potentially associated with positive displacement pumps. Here is a link to more information;

Single-Use Pulsation Dampener

I would strongly recommend you take a look at the "Digital Instruments & Protocols" document that Brooks Instrument published earlier this year. It addresses the advantages to be realized from a digital solution as well as a number of the considerations for each of the most widely utilized protocols. Here is a link to more information;

Digital Instruments & Protocols

While a good problem to have, it is still a problem. I would suggest you take a look at the ArcAir software that is actually available from the supplier of the pH and DO sensors that came with those new bioreactors you mentioned. Here is a link to more information;

ArcAir

I have to admit that at first I thought this was going to be nearly impossible, then I noticed your application. While close, I think the product you are looking for is not the Echo but instead the Ekko. It is a scalable acoustic cell processing tool developed by FloDesign Sonics which is now part of Millipore Sigma. Here is a link to more information;

Ekko

Not that long ago I would have been hard pressed for such a solution, thankfully things have changed. In recent years we have seen the introduction of single-use solutions for most, if not all, bioprocessing applications and sample valves are no exception. The folks at FluidLine Technology have introduced a line of disposable sampling valves that can be either Single-Use (3 cleaning cycles) or Limited Use (12 cleaning cycles). Here is a link to more information;

Fluidline Technology

The virtual environment you are looking for is actually free standing and available in two parts; the first being a Cleanroom and the second being a QC Lab. Among the products featured are particle counters, TOC analyzers, and cell counting/viability analyzers to name just a few. Here is a link to more information and access to the environment;

Beckman Coulter Virtual Experience

It took a bit of doing but I was able to find a small peristaltic pump that meets the requirements you mention. It features independent control of 2, 3 or 4 channels and supports serial communication. I had hoped to offer you more options, but the combination of independent control of 4 channels and serial communication proved a limiting factor for many. Here is a link to more information;

Ismatec Reglo

I'm pleased to report that there are no fewer than 3 company's making spare parts for BioNet bioreactors such as the ones you purchased. They are Applikon, Chemglass and Broadley James. A quick review of their websites indicates that all three have the parts you need. Here are links to more information;

Applikon
Chemglass
Broadley James

I think the product you are looking for is the recently launched CultureOne from Alfa Laval. It features a replaceable insert that includes Alfa Laval's fully hermetic design and UniDisc technology. It is being presented as the first premium separator for single-use bioprocessing. Here is a link to more information;

Alfa Laval CultureOne

Not that long ago I would have been hard pressed for such a solution, thankfully things have changed. In recent years we have seen the introduction of single-use solutions for most, if not all, bioprocessing applications and sample valves are no exception. The folks at FluidLine Technology have introduced a line of disposable sampling valves that can be either Single-Use (3 cleaning cycles) or Limited Use (12 cleaning cycles). Here is a link to more information;

FluidLine Technology

I must admit that when I first saw this question, I concluded there simply was not enough space in the Alert for all the "next generation" bioprocess controllers that cross my path. However, after reading the question again and noting the term "Fix", I concluded one of two things were at work. Either you were looking for the "iFix" product from GE by way of Intellution, which has not been called "next generation" in a long, long time or you were referring to the PHIXED platform. I suspect it is the latter. Although there is not much publicly available to go on, you can use the link below to learn more;

PHIXED

Actually, it is my understanding that what was once in development has now been commercialized in the form of the "Breez" bioreactor from erbi. It is a cassette-based mL scale bioreactor platform enabled with mixing and closed loop pH, DO, Temperature CO2 and Cell Density. I have not had first-hand experience with it yet but people I trust who are affiliated with the platform have good things to say. Use the link below to learn more;

Breez

I would take a look at the products offered by the folks at BlueSens, specifically their BlueInOne Cell. It is a compact gas analyzer capable of measuring in parallel both carbon dioxide and oxygen online as well as in real-time. They are a German firm with a rather long history of addressing bioprocessing applications specifically. Here is the link to more information;

BlueInOne Cell

I would urge you to take a look at the RoSS product from Single Use Support. More than just a stackable container, it offers a number of engineered features designed for optimum storage of both your single use bags as well as the associated connectors and hoses. I have included a link below for your reference;

RoSS

You definitely know what you want, or don't want as the case may be, and I think I have found it. A 202-page doctoral of engineering thesis prepared at University College London with the support not of the manufacturer but of no less an independent source than Eli Lilly. Complete with chapters dedicated to fluid mixing, mass transfer and so much more. Here is a link to more information;

Engineering Characterization of a Rocked Bag Bioreactor for Improved Process development and Scale-Up

Based on my experience, if you are looking for a benchtop instrument dedicated to the accurate and reliable measurement of Osmo then your best bet is the benchtop solution from Advanced Instruments. They are arguably the gold standard for osmolality measurement in our industry. Having enabled some of the most well-known stand alone and integrated bioprocessing solutions. Here is a link to more information;

Advanced Instruments

While I have not had first-hand experience with the product yet, there is an electromagnetic flowmeter that features a disposable flow tube designed specifically for single use bioprocessing applications. The flowmeter is manufactured by the German firm Krohne, whose other products for flow and level measurement I have had success with over the years. Here is a link to learn more;

Flexmag 4050

While in principle it sounds simple enough, moving a bioprocess liquid from one location to another in a manner that is at once fast, reliable and sterile, the practice has proven anything but simple. The products noted below are proven solutions for automating the collection of a sample and delivering it to a bioprocess analyzer.

Flownamics Seg-Flow

Lonza MAST

Nova BioProfile

Securecell Numera

Now this is a classic, from the reference to a 25mm threaded port, to the fact that the port in question is referred to as an 'ingold'. In this case, one classic solution deserves another. I would recommend the Keofitt sampling valve, which is fast approaching its 40th birthday and still going strong with 350,000+ valves rumored to be in operation. Also, since you did not mention if the port on your vessel is the standard or safety design, be sure to double check as this will determine which Keofitt valve length you need for a correct o-ring placement.

Keofit

Based on your description, I think it is safe to say you saw the orbital shaken bioreactor system from Kuhner. I too have seen these systems in operation at conferences and the novel way in which they agitate. The system you describe as being benchtop is likely their SB10 which has a working volume of 3L to 12L. I understand there is also an SB50 and SB200 which will take you all the way up to 200L working volume to ensure scalability. Here is a link to more information; 

Kuhner SB10

With all that has been going on I was wondering how long it would take for this question to come my way. With that in mind, I cheated and have been doing some research. What I came up with is a product called "Tandem" from a firm called Apprentice. It is a really cool solution that allows you to bring the knowledge currently outside your bioprocess suite into the suite, while remaining remote. You will find a link below where you can learn more about this enabling technology.

Apprentice Tandem

While there have been several attempts at a glassless solid-state pH electrode, most notably those based on ISFET technology, their adoption by our community has been less than stellar so we will set those aside. Which brings us to the Diamond FET pH sensor understood to be in development at Yokogawa. As the name implies, it utilizes a semiconductive diamond that delivers both physical robustness and chemical stability. I have included a link to a paper discussing the development of this pH sensor below for your reference. There are other solid-state pH sensors in development, most notable the one out of UC Davis, but Yokogawas' effort best matches your question.

Glassless Solid-State pH Sensor

While there are a number of highly qualified proven solutions for the measurement of individual elements of a bioprocess, the ability to monitor multiple elements of a bioprocess continuously in real-time is currently the role of only two core principles; Raman and Near-Infrared (NIR). However, from my experience, the better solution of the two for bioprocessing is the Raman. Here is a link to the specific platform I would suggest you take a look at;

Kaiser Optical RamanRxn2

Recognizing that your PD scale application will inevitably need the flexibility of scaling-up, and having had first hand positive experiences with many of the folks behind the system, past and present, the Xcell ATF System from Repligen is the way to go. It is truly scalable to your bioprocess, has a proven history of favorable performance and is available in a single-use version if you are interested.

Xcell ATF System

For your application, two single-use pressure sensors immediately come to mind. The first being the PendoTech offering which has a proven history of excellence and with which I have first-hand experience. The second offering being from Parker, which I knew more personally when they were SciLog, and also enjoys a history of excellence. I would urge you to take a look at both and see which best meets your needs.

PendoTech

Parker

The folks at Meissner have published a tech bulletin that speaks specifically to achieving a homogenous solution in one of their single-use containers that might meet your needs. The paper documents in great detail the methodology they used to identify the best practice and is supported by a substantial amount of data.

Conductivity Testing of Mixing Systems

This past December Nova Biomedical introduced their on-line auto sampling solution for the BioProfile Flex 2 known as the OLS. You would likely have seen this solution featured at numerous industry events in recent months if not for the challenges posed by COVID-19. While several firms offer a solution for automated sampling from the Flex 2, the OLS is the only sampling solution that is native to Nova. I have provided a link below to more information.

FLEX2 On-Line Autosampler (OLS)

While there are a host of bioprocess suppliers who provide flow cells, most all of which being commercial off the shelf (COTS), the sensors you mention needing to support made all the difference. I would recommend you take a look at the Hamilton offering of flow cells. I have provided a link where you can learn more.

Hamilton Flow Cells

Not that long ago such a question would have me reaching for the name of a good machine shop. One capable not only of machining the 316 S.S., complete with ports and requisite threads, but of getting the Ra finish on the wetted surface just right, but not today. Instead, I'm going to recommend an industry leading manufacturer of benchtop bioreactors with decades of experience in the design and manufacture of traditional bioreactor headplates, ports and associated accessories. That just so happens to now have the ability to manufacture fully customizable headplates, ports and the like by utilizing 3D printing technology.

AppliFlex ST

With all that has been going on I was wondering how long it would take for this question to come my way. With that in mind, I cheated and have been doing some research. What I came up with is a product called "Tandem" from a firm called Apprentice. It is a really cool solution that allows you to bring the knowledge currently outside your bioprocess suite into the suite, while remaining remote. You will find a link below where you can learn more about this enabling technology. 

Apprentice Tandem

Just when you think you're out, they pull you back in. All kidding aside, it sounds like you should take a look at the Finesse (now Thermo) TruFlow. It is a compact manifold solution designed specifically to address the challenges associated with bioprocess gas management. Per your requirements, it manages up to 6 gases and can direct gases to headspace or sparge. Bonus fact, it was known as the "Zola" during it development. I cannot speak to whether the system is available individually or must be part of a Thermo solution. The link below will provide you with more information.

TruFlow

To answer this question effectively I'm going to have to make the assumption that your application is a bioreactor of some scale. That being said, I would strongly suggest utilizing the FISP product from the folks at Flownamics. It is a proven solution for cell free sampling in bioreactors and fermentors at scales ranging from PD thru Pilot and Large Scale Manufacturing.

FISP

Yes. There is a single-use manifold for fluid transfer that was introduced to our community in the last couple of years that in itself does not require the use of Y connectors, stopcocks and the like. It fits 3/8" tubing ID's and is capable of a max pressure of 15 psi. No word yet if there are plans to accommodate different tubing ID's or if an automated version is in the works. I have provided a link below to more information.

Nordson CYLINDRAFlow Manifolds

This one took some real digging, but I think I found it, a 2015 patent filing from StemBioSys. The patent was for an extracellular matrix derived from human stem cells. If this sounds right to you, then I'm pleased to say that the product has been commercialized as the Cellvo Matrix Plus from StemBioSys. It is described as a novel extracellular matrix derived from human cells that improves relevancy of cell culture studies by recreating the biologically relevant microenvironment to which cells are accustomed. I have provided a link to more information below.

CELLvo Matrix Plus

With all that has been going on I was wondering how long it would take for this question to come my way. With that in mind I cheated and have been doing some research. What I came up with is a product called "Tandem" from a firm called Apprentice. It is a really cool solution that allows you to bring the knowledge currently outside your bioprocess suite into the suite, while remaining remote. You will find a link below where you can learn more about this enabling technology and the company's successful initiative to rapidly deploy it to ensure demand is met.

Apprentice Tandem

Last week, at the annual IFPAC conference in Maryland, Sartorius announced and demonstrated an integration of their industry leading ambr high throughput platform to a Raman spectrometer from Kaiser Optical. Kudos to your co-worker, the integrated solution is being seen by many, including myself, as the next "killer-app" for Raman as it enables the technology to expand beyond manufacturing and into PD. The solution is being called BioPAT Spectro, I have provided a link to more information below.

BioPAT Spectro

I have to admit that at first, I thought this was going to be nearly impossible, then I noticed your application. While close, I think the product you are looking for is not the Echo but instead the Ekko. It is a scalable acoustic cell processing tool developed by FloDesign Sonics which is now part of Millipore Sigma. I have provided a link below for your reference.

Ekko

While there are several MFCs out there to choose from, based on first hand experience from having evaluated many over the years, only two really stand out. They are the Brooks Instrument SLA 5800 and the Burkert 8700 series. If I had to choose between the two, I would lean toward Brooks and its latest Biotech version of the SLA 5800. I have provided links to more information on both below.

Brooks Instrument SLA 5800

Burkert 8700 Series

If the "Dynamic Dialysis" I'm thinking of is the same one you heard about at the conference, then it is actually a combination product and process. The trade name is SpectraFlo and it is available from Repligen. The leading feature of this solution is the utilization of fluidic dynamics to increase purification efficiency. It is this latter portion that makes me think this is the system you heard about.  I have included a link below to more information.

SpectraFlo

Based on the PD nature of your application, and your preference for a single use sensing solution, I would recommend you take a look at the CITSens Bio Process Probe from C-CIT Sensors. It is available in several variations including a high glucose, low glucose or combination of glucose and lactate. As with your pH and DO sensors, the C-CIT offering fits into a standard PG 13.5 thread on your bioreactor headplate and is available in the 120MM or 225mm sensor length you require.

CITSens Bio Process Probe

Two things caught my eye about your need. The first being the delivery of high-speed results while maintaining accuracy. And the second being the ability to support both trypan blue and fluorescence. With that in mind I would recommend you take a look at the Cellaca MX from Nexcelom. Utilizing trypan blue it can do 24 samples in 48 seconds or 2 ½ minutes with fluorescence. I have included a link below to learn more.
Cellaca MX

To be honest, it sounds like your best bet would be to go to a system integrator with a proven track record of delivering such systems. They are more likely to be able to incorporate the specific supplier's equipment you require and give you a control platform that is "open source". However, open source can come in many flavors of controller, everything from DCS's to PLC's so it is best to go to a shop that can offer both and determine which platform best meets your needs. That being said, I would take a look at Panacea Technologies, I have provided a link below for your reference.

Panacea Technologies

Based on my experience, if you are looking for a benchtop instrument dedicated to the accurate and reliable measurement of Osmo then your best bet is the benchtop solution from Advanced Instruments. They are arguably the gold standard for osmolality measurement in our industry. Having enabled some of the most well-known stand alone and integrated bioprocessing solutions. Here is a link to more information;

Advanced Instruments

While I cannot be certain, based on the description of a "novel single-use TFF skid" and the fact the reference point is the Amgen event earlier this week, I would bet that your
colleague came across the single-use TFF skid offering from Artesyn. Here is a link to more information;

Artesyn

Let me precursor this by saying I'm biased. I know, respect and like these people and they make a highly regarded prefabricated cleanroom. That being said I would recommend taking a look at the offering of the folks at G-CON. They are located in Texas so that likely puts them within trucking distance to your site. Of course there are others, but I'm not nearly as familiar with them.

G-CON

I think the solution you are looking for is the "Verifi" platform from ChargePoint Technology. It is my understanding that for the application you asked about, this smart system monitors the activity and temperature of the company's split butterfly valves that are used in containment and aseptic transfer. The clear advantage would appear to be predictive maintenance instead of reactive maintenance. You can learn more by clicking the link provided below;

Verifi

n the interest of clarity, it should be noted that in this instance what is meant by single-use is both the components into which the sample is delivered as well as the sample valve itself. That being clear, there are no fewer than four such solutions I can suggest you take a look at. All have more or less similar functionality, the use of needles for sampling, with the exception of one which is needless. Here are links to each for your reference;

Gore Aseptic Sampling Valve

MilliporeSigma NovaSeptum

Sartorius TakeOne

Thermo Scientific Three60

While many are called, few are chosen and in this case the few is really just two; Pendotech and Parker. With Pendotech having been on the scene nearly since the inception of single-use sensors and Parker coming to the space through the acquisition of SciLog, which itself has been on the scene roughly just as long as Pendotech. Both manufacturers make single-use pressure sensors that deliver performance and reliability, so it really becomes a matter of personal preference. Click on the links provided below to learn more.

Pendotech

Parker/SciLog

Not to put too fine a point on it but you are looking for the wholly grail of single-use sensing, and you just might have found it. Industry leaders Hamilton and Mettler Toledo have both addressed this need and I have seen where Broadley James is working with Pall on a solution that was in Beta testing as of this past Spring. Here are links to more information;

Hamilton Single Use

Mettler Toledo Single Use

Broadley James Single Use

UPDATE: This week ABEC unveiled the newest member of its CSR product family,  a 6,000L working volume single-use bioreactor. 

That distinction would go to the 4,000L working volume CSR product line from ABEC. They actually brought a completely constructed, not an illustration, CSR bioreactor to Interphex in NYC. It is my understanding that Wuxi Biologics has implemented the platform at the commercial manufacturing facility it is constructing in China.

CSR

While at first glance this seems like a simple question, the sheer number of potential suppliers makes a useful response more challenging. Having said that, it sounds like you are trying to prevent overpressure on glass bioreactors between 3L and 15L in size. That being the case, I would recommend talking to the folks at Continental Disc. Their Sanitrx HPX product is available in 25mmm, so suitable for the headplate, and can have a burst pressure of as low as 10 psig, making them able to prevent shattering attributed to overpressure. Here is a link for your reference;

SANITRX HPX

Yes, but I can do better than sending you to generic data. The folks at YMC Process Technologies have created a modeling tool that utilizes your batch data specifically to create a customized estimate of things like reduction in Protein A resin, increase in productivity as well as reduction in buffers that could be realized. Just enter your current or planned process parameters into this tool, run your various use scenarios and you will have the economic insights you need.

YMC Multi-Column Chromatography Modeling Tool

Novasep BioSC Predict Lite

Not that long ago such a question would have me reaching for the name of a good machine shop. One capable not only of machining the 316 S.S., complete with ports and requisite threads, but of getting the Ra finish on the wetted surface just right, but not today. Instead, I'm going to recommend an industry leading manufacturer of benchtop bioreactors with decades of experience in the design and manufacture of traditional bioreactor headplates, ports and associated accessories. That just so happens to now have the ability to manufacture fully customizable headplates, ports and the like by utilizing 3D printing technology.

AppliFlex ST

Based on your description, I think it is safe to say you saw the orbital shaken bioreactor system from Kuhner. I too have seen these systems in operation at conferences and the novel way in which they agitate. The system you describe as being benchtop is likely their SB10 which has a working volume of 3L to 12L. I understand there is also an SB50 and SB200 which will take you all the way up to 200L working volume to ensure scalability.

Kuhner SB10

I'm going to need a DeLorean for this one and go back in time. There are a number of tools available that I can recommend based on first hand, albeit somewhat dated, experience. They include the Membrane Tester, Polarizer, Dust Caps and Calibration Caps. You might also want to take a look at diatomaceous earth (toothpaste) for cleaning the anode/cathode. Here is a link to the BroadleyJames DO Accessories site for your reference. It appears to have everything I remember, but the toothpaste, and I believe these tools work with Mettler and Hamilton DO probes as well, but be sure to check.

Dissolved Oxygen Accessories

To answer this question effectively I'm going to have to make the assumption that your application is a bioreactor or fermentor of some scale. That being said, I would strongly suggest utilizing the FISP product from the folks at Flownamics. It is a proven solution for cell free sampling in bioreactors and fermentors at scales ranging from PD thru Pilot and Large Scale Manufacturing.

FISP

I think the event you are referring to was the bioprocess optimization seminar organized by Flownamics that took place near you. If that sounds about right, then the instrument in question is the Tridex Protein Analyzer from IDEX Health & Science. I have provided a link to more information about the instrument below.

Tridex Protein Analyzer

Yes. A single-use manifold for fluid transfer has been introduced to our community that in itself does not require the use of Y connectors, stopcocks and the like. It is suitable for 3/8" tubing ID's and is capable of a max pressure of 15 psi. No word yet if there are plans to accommodate different tubing ID's or if an automated version is in the works.

Nordson CYLINDRAFlow Manifolds

You're in luck, there is a fully Commercial Off The Shelf (COTS) solution for automated management of up to 6 bioprocess gasses available from Thermo Fisher. The system features thermal mass flow controllers and associated solenoid valves that are integrated into a manifold which follows the gold standard "gas stick" approach to gas management.

TruFlow Gas Manifold

While there are numerous bioprocess analyzers, each with its own strengths and weaknesses, the requirement that the instrument be well suited for not just manufacturing scale mammalian cell culture, but proven GMP compliance, greatly reduces the available options. That being said, I would suggest you take a look at the BioProfile Flex 2 from Nova Biomedical.

BioProfile FLEX2

It took a little digging, but I think I have a couple of products from industry leaders that will enable both your optical dissolved oxygen probes, as well as your conventional pH sensors, to be used with your single-use bags. The beauty of both these products is that they allow you to use sensing solutions that have been proven accurate and reliable in bioprocessing while at the same time fulfilling your need for them to support applications in single-use bags.

Hamilton

Mettler Toledo

It sounds like your colleague got a look at the Seg-Flow S3 from Flownamics, which according to my sources was featured extensively at this year's ESACT conference in Copenhagen. While I have not seen the system first-hand it is my understanding that, while based on the well-known Seg-Flow system, it features a number of improvements in design and functionality. Here is a link to more information as well as images;
Seg-Flow S3

You definitely know what you want, or don't want as the case may be, and I think I have found it. A 202-page doctoral of engineering thesis prepared at University College London with the support not of the manufacturer but of no less an independent source than Eli Lilly. Complete with chapters dedicated to fluid mixing, mass transfer and so much more.

Engineering Characterization of a Rocked Bag Bioreactor for Improved Process development and Scale-Up

You had me worried for a second there, I thought for sure there was no way I was going to be able to get you where you wanted to go. Thankfully your reference to 'Boss' made me realize you had seen the 'Ross' single-use bag storage solution from the folks at Single Use Support. I have included a link to it below.
RoSS

While I was not at Interphex this year, I'm happy to report that I know of that which you speak. The system in question is the Applikon V-Control, a successful collaboration between Applikon and the folks at Emerson to seamlessly integrate DeltaV with Applikon's suite of solutions for bioprocessing. It is my understanding that the platform can manage as many as 32 bioprocesses at scales as low as 250mL to upwards of 50L. The link below will take you to additional information.

V-Control

In the interest of clarity, it should be noted that in this instance what is meant by single-use is both the components into which the sample is delivered as well as the sample valve itself. That being clear, there are no fewer than four such solutions I can suggest you take a look at. All have more or less similar functionality, the use of needles for sampling, with the exception of one which is needless.

Gore Aseptic Sampling Valve

MilliporeSigma NovaSeptum

Sartorius TakeOne

Thermo Scientific Three60

That is one heck of a catch, but you are in luck. For some years now there has been a family of sensors, available in hand held and mounted versions, made by the folks at Bug Lab that meet the requirements you mention. In your question you specify non-invasive, both the hand held and mounted versions of these sensors meet that requirement, so the link below will take you to more information about each.

Bug Lab

I recently came across a White Paper that might be of value to you. It highlights the ability of a new system that utilizes laser induced fluorescence to conduct real-time microbial monitoring of Purified Water, Ultrapure Water and WFI. The result of which being the real-time release of these waters for use in your bioprocess. The link below will take you to the White Paper.

Microbial Monitoring Improves Bioprocess Control

I think the event you are referring to was the bioprocess optimization seminar organized by Flownamics that took place in Cambridge, MA on February 28th. If that sounds about right, then the instrument in question is the Online Protein Analyzer from IDEX Health & Science. I have provided a link to more information about the instrument, including an application study, below.

Online Protein Analyzer

First, thank you for participating in our survey. The insights you shared are much appreciated. Second, Yes!, a small, low cost bioprocess controller like the one mentioned in the survey does exist. The link below will take you to an example of the controller being used for fluid management, and provide you with contact details for the manufacturer.

Flotek Controller

Not that long ago such a question would have me reaching for the name of a good machine shop. One capable not only of machining the 316 S.S., complete with ports and requisite threads, but of getting the Ra finish on the wetted surface just right, but not today. Instead, I'm going to recommend an industry leading manufacturer of benchtop bioreactors with decades of experience in the design and manufacture of traditional bioreactor headplates, ports and associated accessories. That just so happens to now have the ability to manufacture fully customizable headplates, ports and the like by utilizing 3D printing technology.

AppiFlex ST

Based on your description, I think it is safe to say you saw the orbital shaken bioreactor system from Kuhner. I too have seen these systems in operation at conferences and the novel way in which they agitate. The system you describe as being benchtop is likely their SB10 which has a working volume of 3L to 12L. I understand there is also an SB50 and SB200 which will take you all the way up to 200L working volume to ensure scalability.

Kuhner SB10