Andrew Hessel is a futurist and catalyst in biological technologies, helping industry, academics, and authorities better understand the changes ahead in life science. He is a Distinguished Researcher with Autodesk Inc. Bio/Nano Programmable Matter group, based out of San Francisco. He is also the co-founder of the Pink Army Cooperative, the world first cooperative biotechnology company, which is aiming to make open source viral therapies for cancer.
This video, produced by STERIS, walks the viewer through the equipment and processes required for successful gamma irradiation processing.
Standardization of Cell Viability Assays in Primary Cells as a Prerequisite for Novel Bioprocessing Applications
This video provides insights on the standardization of cell viability specific to bioprocessing applications with an emphasis on the requisite assays.
This video, produced by Hamilton Process Analytics, utilizes narration and animation to provide insights into the basics of pH measurement.
This video, produced by Sartorius, provides practical advice for those trying to develop and implement continuous processes. It explains the tools and techniques that can be used during process development and describe how process-scale equipment can be configured to allow effective and predictable scale-up.
This video, produced by Pall Biotech, provides some insights into orthogonal viral controls under continuous processing conditions.
This video, which has 120,000+ views, describes the process by which a biological product-in this case, a pure, concentrated solution of Green Fluorescent Protein (GFP)-is derived from clarified lysate. This is accomplished through multiple variations of two basic procedures: chromatography and filtration.
This video, which has 100,000+ views, describes the process by which a biological product-in this case, molecules of Green Fluorescent Protein (GFP)-is recovered from host e coli cells. The steps of this process are, in very basic terms: (1) separation of cell solids from the broth, (2) disruption of those host cells to release the product contained in them, and (3) isolation of the product through removal of cell debris and other impurities. Tools used to perform these steps include centrifuges, cell disrupters and microfilters.
This video, which has 300,000+ views, describes the role of the fermentation process in the creation of biological products and illustrates commercial-scale fermentation at a cellular level. Included are descriptions of types of fermentation; intracellular, extracellular, types of cells (aerobic, anaerobic), and cell nutrition/media.
In this video, produced by OSIsoft, Poul Waagner Nielsen, Project Manager, Manufacturing Intelligence, at LEO Pharma describes using the PI System as a central warehouse of production data for the people and manufacturing systems in their six factories spread across Europe. Learn More
This video features an interview with Erik Klijn, Senior Data Analytics Lead, at Janssen. During which he discusses the deployment of an OSIsoft PI system to conduct advanced analytics in biopharma manufacturing. This includes an application where the PI system is used to analyze the impact of raw materials on bioreactor performance.
This video, which has 5,000+ views, was produced by the U.S. FDA to explain the concept of interchangeability. The video features an interview with Leah Christl, Ph.D., former Associate Director for Therapeutic Biologics and lead of the Office of New Drugs (OND) Therapeutic Biologics and Biosimilars staff at FDA CDER.
This video, which has 10,000+ views, was produced by the U.S. FDA to address the question of "What are biosimilar products?" The video features an interview with Leah Christl, Ph.D., former Associate Director for Therapeutic Biologics and lead of the Office of New Drugs (OND) Therapeutic Biologics and Biosimilars staff at FDA CDER.
In this video, Kristin O'Neill of Merck & Co. describes how in a PD environment the OSIsoft PI System tracks both bioreactor controller data and automated sampling system data. Merck scientists no longer have to open up their notebooks when they want to compare sample analysis against bioreactor information.
This video, by the AIChE Academy, demonstrates the three regimes of gas mixing in a bioreactor; Flooded, Dispersed, and Recirculation and the methods used to achieve each.
This video, which has 18,000+ views, demonstrates how to prepare an ultralight foam from cross linked gelatin, which can be used to keep cells alive for up to a week at room temperature. No incubator, CO2, dry ice or liquid nitrogen required. The material is easy to make and prepare and the method works for both adherent and suspension cells.
This video, which has 7,000+ views, discusses the use of four electrode conductivity sensors in applications that require a wide measuring range such as fermentation and chromatography. Learn More
This video, which has 30,000+ views, explains anaerobic respiration including the two types of fermentation. Learn More