Presentations

Brian Cox and Robin Ince are joined by Dr Jane Goodall DBE, comedian Bill Bailey and primatologist Dr Cat Hobaiter to find out what we've learnt in the 60 years since Jane first discovered the chimpanzees of Gombe. From tool use, to language and even to culture, her revolutionary work has transformed our understanding of our great ape cousins, and ourselves. The panel chat about how far our understanding has come in that time, and talk about their own unique close-up experiences of chimpanzees, macaques and baboons, and Bill gets a masterclass in how to speak Chimp from a true expert!
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Zea Biosciences is not a typical contract manufacturing organization. The company uses plants to grow recombinant proteins for biologic therapies. To produce a consistent and predictable product, Zea uses a data-intensive approach and grows plants in clean rooms. The end result is a high-scalable platform that is cost-efficient. We spoke to Jim Wilson, CEO of Zea Biosciences, about the company’s approach to producing biologics in plants, why it is a data-intensive process, and the advantages it provides over traditional biomanufacturing.
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Artificial intelligence is working its way into all aspects of pharmaceutical companies’ operations. While much attention has been given to the role these systems can play in drug discovery, IQVIA sees a significant opportunity to use them to transform the area of regulatory compliance. We spoke to Ronan Brown, senior vice president and head of IQVIA Integrated Global Compliance, about the role AI system can play in improving flagging returns on investment in R&D by allowing regulatory departments to operate more efficiently, breakdown data silos within pharmaceutical companies that hamper performance, and allow companies to focus less on rote work and more on regulatory strategies.
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Brian Cox and Robin Ince are joined by actor and writer Mark Gatiss, theoretical physicists Carlo Rovelli and Fay Dowker to ask timely questions about time. Is time real, does it exist in the fundamental laws of physics, and if it doesn't, why do we experience the sensation of time passing? They look at the idea of the block universe, where our future is as real as our past, which worryingly leads to Robin's favourite question about free will...is that an illusion too? A timely look at the question of time and hopefully just in time...
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Bacteriophages have long been used to treat infections. These naturally occurring virus are capable of killing bacteria, but each strain of phage is highly specific. Because of their unique mechanism of action, they provide a potential to address the growing threat posed by multidrug-resistant bacteria, but to treat someone, the right phage must be matched to each patient’s infection. Adaptive Phage Therapeutics believes it’s found a way to create phage therapies suited to treat patients with drug-resistant infections by building a bank of targeted and genomically-screened bacteriophage and testing individual patient’s bacterial colony against that to determine the appropriate phage to treat them. We spoke to Greg Merril, co-founder and CEO of Adaptive Phage Therapeutics, about the origins of the company, how its technology works, and the regulatory hurdles for producing customized therapies to treat individual patients.
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There’s science in everything, even when you don’t realize it. On this episode of StarTalk Radio, Neil deGrasse Tyson sits down with Grammy-award winning composer Eric Whitacre to explore the hidden science of music. Joined by comic co-host Chuck Nice, neuroscientist Heather Berlin, PhD, and mathematician and concert pianist Eugenia Cheng, PhD, we’re investigating how science and mathematics can influence and shape music.
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Have you ever wondered why we do so much scientific testing on fruit flies? Turns out they make better models for humans than you’d think.
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Delivering biologics orally rather than through injection has been an intriguing goal but has proven difficult. Most efforts have focused on finding ways to turn these large protein molecules into formulations where they would not breakdown in the along the digestive tract before they can be absorbed and provide a therapeutic benefit. Rani Therapeutics has taken an unusual tact. Rather than reconceiving the biologic, Rani has reconceived the pill itself. The company has developed what it calls a “robotic” pill that carries the therapeutic to the gut where it injects the drug into the wall of the intestines. We spoke to Mir Imran, chairman and CEO Rani Therapeutics, about how the Rani Pill delivers biologics orally, the technology underlying it, and how the company thinks about the opportunities it will pursue. Learn More

When Fort Knox was built in the 1930s to house America’s gold supply, it was billed as an impenetrable, impregnable, don’t-even-think-of-trying vault. But as the world has moved further away from gold, the stockpile’s lost a bit of its luster. Learn More

How has COVID-19 impacted athletes? We all want sports to continue competition, but at what cost? On this episode of StarTalk Sports Edition, Neil deGrasse Tyson and co-hosts Gary O’Reilly and Chuck Nice are investigating the impact of COVID-19 on athletes with Dr. Saurabh Rajpal, MD, cardiovascular disease specialist and Assistant Professor at The Ohio State University Wexner Medical Center and Dr. James Borchers, MD, Head Team Physician for The Ohio State University and Medical Director for the Athletic Department at OSU. Learn More

For centuries North American tribes have told stories of a hairy wild giant in the wilderness, and once Europeans arrived they claimed to see it, too. Chuck and Josh examine the claims of believers and the rebuttals of skeptics in this evenhanded episode from the SYSK archives. Learn More

If you want to control the masses, control what they read. After all, books are seeds that germinate new points of view. As a result, the struggle against banning books is contentious and continual. Learn More

We keep hearing that a Yellowstone supervolcano could blow at any moment — and possibly wipe us all out. So is Yellowstone overdue for the BIG ONE, and if it happens, how bad could it be? To find out, we talk to paleoecologist Dr. Gill Plunkett, Yellowstone Volcano Observatory Scientist-in-Charge Dr. Mike Poland and Washington resident Christian Jacobsen.  Learn More

The idea of paying Black Americans reparations for slavery has been around for a long time, but it’s starting to get more support than ever. So we ask: If the country does agree to pay up, how do you calculate the bill? And how could the U.S. come up with that kind of cash? To find out, we talk to historian and farmer Leah Penniman, economist Prof. William Darity Jr., public policy scholar Assistant Prof. Naomi Zewde, and Ebony Pickett. Learn More

Have you ever had the feeling that someone or something is watching you? Perhaps you even feel a tingle on the back of your neck. In this episode of Stuff to Blow Your Mind, Robert and Joe explore this creepy feeling, research into its perception and what it means to meet another being’s gaze. Learn More

Sushi grew out of a way to ferment fish a couple thousand years ago and in the late 20th century began to take the world by storm. What began as traditional, rigid food has come to evolve with new delicious innovations being added to the original canon. Learn More

For at least sixty years a mysterious person (or persons) showed up at Edgar Allen Poe’s grave to toast the master on his birthday. No one ever found out who this legendary figure was. Learn More

Without wind tunnels we may not have airplanes right now. Early aviationists built them to puzzle out how to get and stay airborne. But wind tunnels are used for so much more than flight - from microchips to wind turbines. Learn More

Sweepstakes were invented as marketing tools to drum up interest for a product or sales. But winning them can be fun and as they've proliferated an entire subculture of people who enter hundreds of them a day. Learn More

Are sharks the super-predators we think they are? Or have we been baited with great white lies? To find out, we interviewed shark researchers Dr. Taylor Chapple, Dr. Tricia Meredith and Dr. Chris Pepin-Neff, along with surfer Mike Wells. Learn More

When a race car hits the wall at 200 mph, how much force is involved? How much energy is behind a punch to the face? On this episode of StarTalk Sports Edition, Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O'Reilly are investigating the physics of all the hard hits you love in sports. Learn More

Silicon Valley seems to be constantly pumping out "solutions" to fix our broken food system. The latest and greatest: cell-cultured meat - meat that's grown in vats, without needing to kill animals. Companies say their new techy meat will be safe and better for the planet than what we have now. We join forces with Chase Purdy, author of "Billion Dollar Burger," to find out if this stuff is all it's cracked up to be. Learn More

For centuries, people have been looking to the stars to tell us all kinds of things - what our future holds, who we should date. So what does the science say about astrology? It turns out, there's some surprising stuff here. We speak to astronomer Prof. Caty Pilachowski, Prof. Dave Henningsen and astrology lover Natalie Norman. Learn More

An adventuring Swedish doctor takes on a decades-long medical mystery: What exactly was the 1918 flu? We talk to Dr. Johan Hultin, Eileen Hultin, Dr. Jeffery Taubenberger, Ann Reid, Rita Olanna and Annie Conger. Learn More

The creation of atomic weaponry changed human civilization forever, but it also left its mark on the Earth itself -- in both obvious and subtle ways. In this episode of Stuff to Blow Your Mind, Robert and Joe discuss some of the ways in which the world would not be the same. Learn More

There are so many ways to fall-in love, asleep, even flat on your face. This hour, Radiolab dives into stories of great falls. We jump into a black hole, take a trip over Niagara Falls, upend some myths about falling cats, and plunge into our favorite songs about falling. Learn More

In this episode of Stuff to Blow Your Mind, Robert and Joe consider the cognitive effects of driving. How does it alter our perceptions of self? How might driving prevent cognitive decline? What are the benefits of automotive ergonomics and how do we avoid the risks of road rage is aggressive? Learn More

Rabies may have gotten a lot of attention in the U.S. in the 70s and 80s, but it's still an issue in developing countries. Learn all about this nasty virus in this classic episode. And stay away from raccoons and bats. Learn More

It's actually really strange that scratching your head is a widely understood sign that you're puzzling over something. No one's exactly sure why we do that, so interesting theories abound! Learn More

The story of how a chant and a shirt came to dominate one of baseball's biggest rivalries, thanks to a group of hardcore punks from Boston. Starting in 1999, a group of kids infiltrated Fenway Park with one of the most popular bootleg t-shirts in sports history - a shirt that became the emblem of the moment the Red Sox and Yankees rivalry was turned on its head. Learn More

Is there life on Venus? On this episode of StarTalk Radio, Neil deGrasse Tyson, comic co-host Paul Mecurio, and astrobiologist David Grinspoon, aka Dr. FunkySpoon, are investigating the discovery of phosphine gas in the atmosphere of Venus. Learn More

When you vote in an American presidential election, you're not voting for your candidate - you're voting for a group of people you hope will in turn vote for your candidate. Listen in to learn more about the strange process for electing the president, in this classic episode. Learn More

It's time to get jazzed up for some Earth science of the waterlogged variety. Join Chuck and Josh as they tour some of the most interesting ecosystems on the planet and learn why we need to stop destroying them post haste. Learn More

Is a COVID-19 vaccine likely in the near future? On this episode of StarTalk Radio, Neil deGrasse Tyson and comic co-host Paul Mecurio answer your fan-submitted Cosmic Queries about vaccines for COVID-19 with the help of their guest, Dr. Paul Offit, MD, Director of the Vaccine Education Center and an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia. Learn More

By longstanding listener request, we look at how Hawaii was basically stolen by the United States in the 19th century. Rather than reverse this bit of geopolitical fraud, the US ended up making Hawaii a state instead. Learn More

In 2012, poker star Phil Ivey pulled off an elaborate baccarat scheme that won him over $20 million and landed him in court. But Ivey had another card up his sleeve - a secretive mastermind named "Kelly" Cheung Yin Sun, who crafted the scheme to get revenge. A Queen of Sorts dives into the world of high stakes gambling, and what happens when a casino underestimates an Asian woman. Learn More

Twenty years ago, hundreds of women answered a classified ad seeking intrepid adventurers for an all-women trek to the North Pole - no expedition experience necessary. On the ice, 20 of those women came face to face with just how deadly the Arctic can be, along with the supreme beauty of the top of our planet. They also discovered something in themselves that changed their lives forever. Learn More

Throughout his hall of fame career, John Madden's passion wasn't just for playing and coaching football- he was driven to bring the nuances of the game to the masses. In the late 1980s, a golden opportunity fell into his lap via an upstart company called Electronic Arts. Will Wheaton narrates the story of how Madden built a video game empire - and pushed the limits of gaming. Learn More

The 2003 World Series of Poker should not have been a success. Its host casino teetered on the edge of bankruptcy, internet qualifiers knocked out the most marketable stars, and the production company tasked with showing the event on TV knew nothing about the game. All In explores how the 2003 tournament overcame the odds to spark a poker boom and forever change poker's place in America. Reported by Keith Romer. Learn More

White-collar crime often involves fraud and other nonviolent acts. For most people, the term "white-collar crime" conjures up images of CEOs conniving their way to fortune. But what is it, really? Learn More

The 1992 Olympic Summer Games in Barcelona produced a great many heroes, but in the months leading up to the Games, television viewers were led to believe that they were all about decathletes Dan O'Brien and Dave Johnson - who were competing not only for the United States but for Reebok, as well. The ad campaign cost some $25 million and made them stars. 25 years later, we revisit the hype, how the campaign went bust - and Dan O'Brien's path to redemption. Learn More

According to local legend, the Louisiana Superdome was always a haunted place. First plagued by construction problems, then years of bad luck for the host Saints team - by 2005 those Saints were prepared to abandon the stadium in favor of a dreaded move to San Antonio. Then Hurricane Katrina hit, and somehow the dome became a symbol for a city's rebirth. This is the story of New Orleans, through the story of its dome. Narrated by Tarriona "Tank" Ball of Tank and the Bangas. Learn More

The 1999 Women's World Cup transformed Mia Hamm, Julie Foudy, and the National Team into celebrities overnight. They used their newfound fame to launch the world's first women's professional soccer league: WUSA, the Women's United Soccer Association. But mismanagement and tension with the U.S. Soccer Federation put the league's future in jeopardy. This is the story about how the stars of the '99 World Cup Team built a league from scratch and fought to keep it alive. Learn More

Lichen are incredibly widespread and easy to take for granted, but these composite organisms are some of the most fascinating lifeforms on the planet. Learn More

In the middle of the Cold War, Romanian gymnastics coaches Bela and Martha Karolyi turn Nadia Comaneci, a 14-year-old gymnast from a Communist country, into a global symbol of excellence at the 1976 Olympics when she scores the first perfect 10. But Romania becomes too controlled for Bela's ambitions, and the Karolyis set their sights on the freedom of the United States. Learn More

Browse the libraries of the world and you'll find nothing stranger and perplexing than the so-called Voynich Manuscript, a 15th century tome that has perplexed linguists and codebreakers for hundreds of years -- and remains a mystery. Learn More

Six years ago, a new infection began popping up in four different hospitals on three different continents, all around the same time. It wasn't a bacteria, or a virus. It was ... a killer fungus. No one knew where it came from, or why. Today, the story of an ancient showdown between fungus and mammals that started when dinosaurs disappeared from the earth. Back then, the battle swung in our favor (spoiler alert!) and we've been hanging onto that win ever since. But one scientist suggests that the rise of this new infectious fungus indicates our edge is slipping, degree by increasing degree. Learn More

Browse the libraries of the world and you'll find nothing stranger and perplexing than the so-called Voynich Manuscript, a 15th century tome that has perplexed linguists and codebreakers for hundreds of years -- and remains a mystery. In this episode of Stuff to Blow Your Mind, Robert and Joe discuss just why we can't stop looking to its weird pages. Learn More

Masks. Since the early days of the pandemic, it's been tough to nail down how much they can really do to slow down the spread of the virus. We speak to industrial hygienist Dr. Rachael Jones and share some new science that puts the final nail in the coffin of this debate. Learn More

Entire TV shows are dedicated to them and Americans love to watch a live one, but police chases aren't as routine as they seem. While police assert chases are important tools, critics say cops engage in chases too often and too easily. Learn all about the what, how, and why in this classic episode. Learn More

Probiotic-crammed foods and pills are marketed as charmers of the human microbiome - and the key to immune, gut and brain health. But how much does the microbiome actually matter, and do probiotics live up to the hype? To learn more we talked with biomedical engineering professor Ilana Brito, immunologist Dr. Yasmine Belkaid, psychiatry professor Ted Dinan, and microbiologist Dr. Namrata Iyer. Learn More

In 1962, three ordinary criminals transcended into folk heroes when they crawled out of their cells in Alcatraz Federal Penitentiary took to the water in a homemade raft and were never heard from again. Could they have possibly survived? Learn More

Almost three percent of Americans suffer from a debilitating disorder that causes them to suffer intense fear seemingly without reason and science hasn't yet figured out what causes it. Join Josh and Chuck in this classic episode as they get to the bottom of panic attacks. Learn More

On this episode of StarTalk Radio, Neil deGrasse Tyson and comic co-host Chuck Nice are exploring grit. What is grit? You've heard the term, you probably have a vague understanding of what it means, but what does it really mean? What better way to find out than with Cosmic Queries? Learn More

Unless you have an arcane disorder from a lesion on a very specific spot on our medulla, the chances are you sneeze. Turns out most animals do it, even lizards! Learn the whys and hows of this most interesting involuntary reflex. Learn More

In addition to all the lousy things that's come out of the Coronavirus pandemic, the U.S. is also experiencing a coin shortage thanks to a stalled-out economic system that normally circulates coins. Learn More

There's a movement afoot that says we should all stop thinking about our weight and just enjoy food. No, it doesn't help you lose weight...No, it's not a diet...No, - just listen to the episode, okay? Learn More

On this episode of StarTalk Radio, Neil deGrasse Tyson and comic co-host Jordan Klepper are together again to answer fan-submitted Cosmic Queries about sharks. Since both Neil and Jordan are self-proclaimed non-experts on sharks, they're joined by shark scientist Jasmin Graham. Learn More

When we think of China today, we think of a technological superpower. From Huawei and 5G to TikTok and viral social media, China is stride for stride with the United States in the world of computing. However, China's technological renaissance almost didn't happen. And for one very basic reason: The Chinese language, with its 70,000 plus characters, couldn't fit on a keyboard. Today, we tell the story of Professor Wang Yongmin, a hard headed computer programmer who solved this puzzle and laid the foundation for the China we know today. Learn More

If it was possible to take a full scan of all of the DNA of every cell in and on your body the results would be startling: Only 1 percent would be human. The other 99 percent comprises all of the bacteria, fungi, viruses and other microbes you literally cannot live without. Learn more in this classic episode. Learn More

Sometimes providence smiles on historians. Thus is the case with the Rosetta stone, an ancient Egyptian tablet that served as the key for unlocking hieroglyphics, lost to time for a millennia. In this classic episode, learn about the international intrigue, rivalry to translate it and the luck that led to the founding of Egyptology. Learn More

When Michael Jackson debuted the moonwalk in 1983 the world was enrapt. The dance goes back farther, to the 1930s, and pops up again in the 50s, before reappearing via mimes and West Coast poppers in the 70s. Follow the circuitous route of an iconic move in this classic episode. Learn More

Do we control technology or does technology control us? On this episode of StarTalk Radio, Neil deGrasse Tyson joins forces with first-time comic co-host Negin Farsad and material scientist and engineer Ainissa Ramirez, PhD, to explore how technology has shaped the world as we know it. Ainissa is also the author of a new book The Alchemy of Us: How Humans and Matter Transformed One Another. Learn More

Ever feel like everyone in the Zoom call is looking at you? Ever astonished to find your contribution to a project goes unrecognized, or that your latest faux pas didn't destroy you? Perhaps you're not the central character in this narrative after all. In this episode of Stuff to Blow Your Mind, Robert and Joe explore the spotlight effect and what it teaches us about our own perception of reality and those around us. Learn More

As scientists have been scrambling to find new and better ways to treat covid-19, they've come across some unexpected allies. Invisible and primordial, these protectors have been with us all along. And they just might help us to better weather this viral storm. To kick things off, we travel through time from a homeless shelter to a military hospital, pondering the pandemic-fighting power of the sun. And then, we dive deep into the periodic table to look at how a simple element might actually be a microbe's biggest foe. Learn More

What's the difference between being a skeptic and believing in conspiracy theories? How do you remain skeptical without falling down a rabbit hole? On this episode of StarTalk Radio, Neil deGrasse Tyson and comic co-host Chuck Nice catch up with Michael Shermer, Founding Publisher of Skeptic Magazine and author of Giving the Devil His Due: Reflections from a Scientific Humanist, to explore conspiracy theories and the COVID-19 pandemic. Learn More

In this episode of Stuff to Blow Your Mind, Joe chats with Kat Arney about her upcoming book "Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal." Learn More

How do you actually make change in the world? For 126 years, Mississippi has had the Confederate battle flag on their state flag, and they were the last state in the nation where that emblem remained "officially" flying.  A few days ago, that flag came down. A few days before that, it coming down would have seemed impossible. We dive into the story behind this de-flagging: a journey involving a clash of histories, designs, families, and even cheerleading. Learn More

The robber barons were not a group of evil super villains. OR WERE THEY? Learn all about these titans of industry from the Gilded Age in today's episode. Learn More

It's hard to imagine what the world will look like when COVID-19 has passed. So in this episode, we look back to the years after 1918, at the political, artistic, and viral aftermath of the flu pandemic that killed between 50 and 100 million people and left our world permanently transformed. Learn More

An old coal mine in Pennsylvania caught fire one day in the 60s and it's been burning ever since. What's crazy is this happens all the time. Learn More

We're six months into this coronavirus pandemic, which has shaken the world and stunned scientists. What have we learned? Where are we headed? To find out, we talk to virologist Professor John Dennehy, virologist and immunologist Professor Ann Sheehy, and hospital epidemiologist Dr. Cassandra Pierre. We also check back in with Dani Schuchman, who is now three months into his recovery from Covid-19. Learn More

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, member of the White House Coronavirus Task Force and America's favorite nerd joins Science Vs again. Wendy chats with Dr. Fauci about the pandemic's past, present and future. Learn More

Well-planned landfills have only recently come into widespread use. Recently, waste managers have found that they work a little too well and now the landfill is being reinvented. Learn More

Sure, together Young Guns and Young Guns II form an exhaustive biography of Billy the Kid's life. But did you know they also contain misleading information? Billy the Kid may not have lived to 100 under an alias after all! Learn More

For more than half of the 20th century parents in the industrialized world were freaked out by an unseen waster of youth, the poliovirus. It spread easily and could paralyze children for life or even kill them. Its effects were so horrible that humanity set about ridding if from the Earth. Learn More

People have believed something strange lives in Loch Ness for at least 3500 years. Thousands of people have sighted the Loch Ness Monster and dozens of expeditions have been launched. But does the fact that nothing's been found mean it's not real? Learn More

In 2018, director Spike Lee brought the story of Ron Stallworth to the big screen to great effect. Today, Josh and Chuck discuss the true story behind the Oscar nominated film. Learn More

If you've ever had a bumpy airplane ride, you know it's nothing fun. But have you ever noticed that the pilots sometimes tell you ahead of time to buckle in? How do they know turbulence is ahead? Are they some kind of fortune teller? How can anyone see wind? Learn More

While the search for Atlantis has been pushed to the fringes since the 19th century, archaeologists have quietly pursued cities that may have inspired Plato to fabricate the mythical city. It looks like a team in Greece has found it. Learn More

Have you ever wondered what happens to all those campaign donations when a political campaign goes belly up? Or, even worse, is in debt! Wonder no more! Learn More

There have been a lot of studies over the years regarding birth order. Some conclude that it's a big deal, while others more or less discount its importance. Learn More

Barcodes are everywhere. Those little lines and numbers that make up one of the most recognizable barcodes, the UPC, was designed to make going to the grocery a lot less miserable. It ended up becoming the central symbol of the global economy. Learn More

Speaking in public is frequently cited as people's number one fear, even more fearful than death. Most people go through life avoiding public speaking, but it turns out that only makes things worse. The best medicine? Public speaking. Learn More

The secret military base Area 51 is inextricably linked to every secret, shady project the US government is rumored to be involved in - from reverse-engineering alien technology to coordinating a one-world government. The truth is much more mundane. Learn More

Live Aid was a revolutionary concert event in two countries in 1985 that spanned the world via satellite. The brainchild of musician Bob Geldof, it really did help change the world in many ways, but its direct impact on Ethiopian famine relief remains in question. Learn More

  • Insulin is a relatively low-priced drug
  • Chronic nature of Diabetes means the cost for insulin treatment is high, and together with an increasing number of patients
  • This financial burden challenges healthcare systems worldwide
  • Its price reduction is needed in order to improve its availability especially in lower to lower-middle income countries Fig. 1 Insulin in the form of infusion

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Original Publication Date: 03/18/2019

The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality. Single-pass tangential flow filtration (SPTFF) can be used to intensify manufacturing processes to meet these goals. Here, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity. This intensified polishing approach can be linked with upstream steps for a more continuous process which eliminates tankage and hold time, and enables the use of smaller polishing columns to improve productquality at higher throughputs.

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Original Publication Date: 11/10/2017

Tangential Flow Filtration (TFF) is a separation process that uses membranes to separate components in a liquid solution or suspension on the basis of size or molecular weight differences.
Pellicon® cassettes combine the advantages of efficient, gentle processing, and linear scalability for effective, predictable scale-up from laboratory to process applications.

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Original Publication Date: 07/04/2017

Evaluate high pressure refolding

  • For our specific manufactured molecular formats on a variety of model proteins
  • Develop experimental approach for fast optimization of process parameters
  • Compare structure, stability, and activity of the protein variants refolded with high pressure vs. conventional methods
  • Identify potential economic benefits of high pressure compared with conventional refolding

Evaluate high pressure for the dissolution of soluble protein aggregates

  • Using process-related aggregates of a relevant model protein
  • Show that solubilized monomers have native structure

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Original Publication Date: 10/26/2016