Solution Alert

First, let me say upfront that I consider 'outside the box' to be a term of endearment. However, it is a term that can be used to describe just a handful of system integrators in our bioprocessing community. Having said that, based on your location, I'm going to assume you would prefer that the integrator have a strong presence on the West Coast of the U.S. And knowing that your site is a user of the DeltaV platform, I will assume you need them to be proficient in DeltaV. If those two assumptions are true, and 'outside the box' is what you are looking for, then I would suggest you speak to the folks at AES.

AES

I'm going to need a DeLorean for this one and go back in time. There are a number of tools available that I can recommend based on first hand, albeit somewhat dated, experience. They include the Membrane Tester, Polarizer, Dust Caps and Calibration Caps. You might also want to take a look at diatomaceous earth (toothpaste) for cleaning the anode/cathode. Here is a link to the BroadleyJames DO Accessories site for your reference. It appears to have everything I remember, but the toothpaste, and I believe these tools work with Mettler and Hamilton DO probes as well, but be sure to check.

DO Accessories

In recent years there has been a lot of work done to address the need for ultra-low-temperature bioprocessing solutions. One example is the recently introduced AdvantaSil ultra-low-temperature silicone tubing from AdvantaPure which should more than meet your needs. On a related note, if you find yourself looking for a container for this application you would be well served to take a look at the also recently introduced Gore STA-PURE Flexible Freeze Containers.

AdvantaSil Ultra Low Temperature Silicone Tubing

STA-PURE Flexible Freeze Containers

In recent years there has been alot of work done to address the need for ultra low temperature bioprocessing solutions. One example is the recently introduced AdvantaSil ultra low temperature silicone tubing from AdvantaPure which should more than meet your needs. On a related note, if you find yourself looking for a container for this application you would be well served to take a look at the also recently introduced Gore STA-PURE Flexible Freeze Containers.

AdvantaSil Ultra Low Temperature Silicone Tubing

STA-PURE Flexible Freeze Containers

To answer this question effectively I'm going to have to make the assumption that your application is a bioreactor or fermentor of some scale. That being said, I would strongly suggest utilizing the FISP product from Flownamics. It is a proven solution for cell free sampling in bioreactors and fermentors at scales ranging from PD thru Pilot and Large Scale Manufacturing.

FISP

Recognizing that your PD scale application will inevitably need the flexibility of scaling-up, and having had first hand positive experiences with many of the folks behind the system, past and present, the Xcell ATF System from Repligen is the way to go. It is truly scalable to your bioprocess, has a proven history of favorable performance and is available in a single-use version if you are interested.

Xcell ATF System

While there are a number of highly qualified proven solutions to the measurement of individual elements of a bioprocess, the ability to monitor multiple elements of a bioprocess continuously in real-time is currently the role of only two core principles; Raman and Near-infrared (NIR). The successful implementation of those principles as products specific to bioprocessing appear below;

Kaiser Optical RamanRxn2 (Raman)

Sartorius Stedim BioPAT Spectro PND500 (NIR)

While for many years the demand upon bioreactor manufacturers was to ensure scalability to larger and larger vessels, that is increasingly less often the case today. Instead, end users are seeking bioreactors, sometimes referred to as "mini-bioreactors", that have design and control features similar to their larger cousins so as to best enable a scaling down of their bioprocess. Here are some industry leading examples;

ambr250 - Sartorius

DASbox - Eppendorf

MiniBio2 - Applikon

While there are many challenges facing our community, among the more immediate have to do with the collection and utilization of data associated with our bioprocesses, and the use thereof for their optimization. The products noted below have been developed to leverage said data to achieve the desired optimization.

Applied Materials SmartFactory RX

Applikon Lucullus PIMS

OSIsoft PI System

Seeq R Series

Bio-G Software Suite

The ongoing adoption of single-use solutions for applications in bioprocessing has led to the debut of not one but five and counting pump solutions that feature single-use wetted components. The pumps below address a wide range of applications in bioprocessing at an assortment of scales.

Watson Marlow Quantum

Quatroflow QF Single-Use

Levitronix PuraLev Single-Use

Cole-Parmer Masterflex QF Single-Use

Quantex Single-Use

Yes. Recently a single-use manifold for fluid transfer was introduced to our community that in itself does not require the use of Y connectors, stopcocks and the like. It fits 3/8" tubing ID's and is capable of a max pressure of 15 psi. No word yet if there are plans to accommodate different tubing ID's or if an automated version is in the works.

Nordson CYLINDRAFlow™ Manifolds

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