Patent Alert

A U.S. Patent Application for "Seeding an Adherent Cell Bioreactor with Non-Adherent Cells Increases Seeding Density Limit and Reduces Required Expansion Time" was published by Trizell on September 12th, 2019. The present invention is a counter-intuitive way to improve the commercial-scale production of recombinant biological products in adherent-cell bioreactors, which reduces the risk of cell culture contamination, increases total yield and reduces the delay between seeding and harvest, thus minimizing expression product degradation, by inter alia inoculating an adherent culture bioreactor with suspension-adapted producer cells. Learn More

A U.S. Patent Application for the "Detection of pH Utilizing Raman" was published by UK Research & Innovation on September 12th, 2019. The present invention includes methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features. Learn More

A U.S. Patent Application for "High Efficiency Continuous Countercurrent Tangential Negative Chromatography" was published by Chromatan on September 12th, 2019. The present invention is a system, module and method for continuous or batch single-pass countercurrent tangential chromatography for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules. The resin slurry flows in a continuous single pass at steady-state through each module, while corresponding buffers flow countercurrent to the slurry facilitating efficient product and impurity extraction. Learn More

A U.S. Patent Application for a "Chromatography Medium" was published by Puridify on September 12th, 2019. The present invention is a chromatography medium comprising one or more electrospun polymer nanofibres wherein the electrospun cellulose nanofibers are fused together at points where the nanofibers intersect one another, and which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate, and wherein the chromatography medium has affinity chromatography protein ligand surface functionality interactive with target molecules. Learn More

A U.S. Patent for a "Particle Sensor with Interferent Discrimination" was awarded to BugLab on September 10th, 2019. The present invention provides methods and devices to measure particle suspension concentrations in the presence of potential interferents. Particle back-scatter readings are taken at light wavelengths that are absorbed by the medium before interacting with surrounding objects. Source-detector spacings are minimized compared to the mean absorbance path length of light, thereby maximizing the range of sensitivity to particle concentration. The active discrimination against potentially interfering particles, such as bubbles, is provided. Learn More

A U.S. Patent for a "Reagent Usable for the Isolation and/or Purification of Nucleic Acids" was awarded to Qiagen on September 10th, 2019. The present invention provides a special reagent for the pretreatment of sample materials. The pretreatment with the reagent according to the invention enables the isolation of nucleic acids by a uniform method from very diverse sample materials, in particular different bioprocess samples, even if the nucleic acids are only present in small amounts in the sample materials. The reagent used for the pretreatment comprises, as key component, at least one compound comprising an amino group. Learn More

A U.S. Patent Application for a "Signal Polypeptide for Improved Secretion of Protein" was published by MedImmune on September 5th, 2019. The present invention relates to a signal polypeptide for improving excretory production of a heterologous polypeptide, proteins comprising the signal polypeptide, nucleic acids encoding the signal polypeptide, and methods of producing thereof. Exemplary embodiments include an improved signal polypeptide attached to alpha toxin, and methods to produce and isolate alpha toxin. Learn More

A U.S. Patent Application for "Multivariate Spectral Analysis and Monitoring for Biomanufacturing" was published by Genzyme on September 5th, 2019. The present invention features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit. Learn More

A U.S. Patent Application for "Chromatography Column Packing Medium Recovery" was published by Repligen on September 5th, 2019. The present invention includes a chromatography column tube having an inlet and outlet and port assembly arranged in a wall of the column tube between flow distributors that together form a chamber within the tube that is filled with packing medium are described. The port assembly facilitates the removal of resin from the pre-packed column and the port assembly does not affect fluid flow in the normal use of the column for chromatographic separation or ability to maintain sanitary conditions within the column. Learn More

A U.S. Patent for "Cell-Sorting Method and Associated Device" was awarded to Commissariat a L'Energie Atomique on September 3rd, 2019. The present invention is a method of discriminating a living cell from a dead cell, and a device for implementing the method, the method including: using a lens-free imaging device to acquire a diffraction figure corresponding to a cell; and determining a light intensity on a central area of an elementary diffraction figure associated with the cell. It can thus be determined if the studied cell is a living cell or a dead cell. Learn More

A U.S. Patent for "Compact Spiral-Wound Filter Elements, Modules and Systems" was awarded to MilliporeSigma on September 3rd, 2019. The present invention is a spiral-wound filter element comprising: a) a feed channel having a height of less than about 450 .mu.m and a length that is less than about 800 times the feed channel height, the feed channel including a mesh fiber feed screen; b) a permeate channel having a height of less than about 300 .mu.m, the permeate channel including a mesh fiber permeate screen; and c) a filtration membrane having a pore size in the range of about 1 nm to about 100 nm. Learn More

A U.S. Patent for "Sequencing Methods" was awarded to 10K Genomics on August 27th, 2019. The present invention described herein solves challenges in providing a proficient, rapid and meaningful analysis of sequencing data. Methods and computer program products of the invention allow for a system to receive, analyze, and display sequencing data in real-time. The invention provides solutions to several difficulties encountered in assembling short sequencing-reads, and by doing so the invention functions to improve the worth and significance of sequencing data. Learn More

A U.S. Patent for a "Method of Viral Purification" was awarded to GlaxoSmithKline  on August 27th, 2019. The present invention is a method of producing a virus in cell culture comprising at least the steps of: a) providing a population of cells in a cell culture medium, b) infecting the population of cells by: i. inoculating the population of cells with the virus, and ii. incubating the inoculated population of cells so as to allow the virus to replicate and propagate, c) collecting the produced virus, thereby providing a viral harvest, and d) purifying the virus, wherein a volumetric power input of at least 15... Learn More

A U.S. Patent Application for a "Process for Improving the Dissolution Behavior of Components in Aqueous Solutions" was published by MilliporeSigma on August 22nd, 2019. The present invention relates to a process for improving the solubility or dissolution behaviour of components in an aqueous solution. The dissolution properties of a slowly/badly dissolving component can be positively affected by generating mixed particles of this component with another component which has a negative dissolution enthalpy. By preparing and adding such mixed particles solubility is improved without changing the chemical composition. Learn More

A U.S. Patent Application for a "Virtual Transmitter for Bioreactor Automation System" was published by Finesse on August 22nd, 2019. The present invention includes a probe for measuring a condition in a bioreactor that can generate a signal. Measured conditions may include pH, DO, temperature, and pressure. The signal can travel to an electronic card capable of converting the signal from analog to digital and the card can then send the converted signal to a digital controller. The condition monitoring and control system eliminates hardware redundancies and increases versatility by then displaying the converted signal in a software-based virtual transmitter on a non-dedicated human machine interface. Learn More

A U.S. Patent on "Media for Culturing Stem Cells" was awarded to the Technion Research & Development Foundation on August 20th, 2019. The present invention is a well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. Learn More

A U.S. Patent for a "Process of Recycling Mixed PET Plastic Articles" was awarded to Carbios  on August 20th, 2019. The present invention relates to a method for recycling at least one mixed PET plastic article, the method comprising degrading at least PET of the mixed PET plastic article to monomers and/or oligomers using an enzyme and recovering the resulting monomers and/or oligomers. The method of the invention may be used for depolymerizing, simultaneously or sequentially at least two different polymers of the mixed PET plastic article, and/or for recycling at least two mixed PET plastic articles. Learn More

A U.S. Patent Application for an "Apparatus for Detecting pH and Dissolved Oxygen" was published by Scientific Industries  on August 15th, 2019 . The present invention is a cell culture monitoring system that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Learn More

A U.S. Patent for "Highly Concentrated Pharmaceutical Formulations" was awarded to Genentech  on August 13th, 2019 . The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab<CD20>, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-CD20 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. Learn More

A U.S. Patent for "Methods for Suspension Cultures of Human Pluripotent Stem Cells" was awarded to Janssen on August 13th, 2019. The present invention is an in vitro method of producing three-dimensional cell clusters of pluripotent stem cells comprising the steps of: a. treating pluripotent stem cells cultured in a planar adherent culture with a chelating agent or enzyme to release cell aggregates from the planar adherent culture; b. suspending the cell aggregates from the planar adherent culture in a culture medium in the presence of a Rho-kinase inhibitor without centrifuging the cell aggregates and without dissociating the cell aggregates to single cells. Learn More

on August 13th, 2019. The present invention  is a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce.  Learn More

A U.S. Patent Application for a "Reversible Liquid Filtration System" was published by Sartorius Stedim on August 8th, 2019. The present invention is a reversible liquid filtration system for cell culture perfusion comprises: a bioreactor vessel (B4), for storing the cell culture (L4); a perfusion pump (P7), comprising a reciprocable element (P71) which is movable in opposing first and second pumping directions (dF, dR); a filter (F4); and first and second bi-directional valves (BV1, BV2), each selectively controllable between open and closed positions. The perfusion pump (P7), the filter (F4), and the first and second bi-directional valves...  Learn More

A U.S. Patent Application for a "Chromatography Method" was published by GE on August 8th, 2019. The present invention is a method of making affinity chromatography beads suitable for purification of immunoglobulin containing proteins or parts thereof, from contaminants that are larger than immunoglobulin containing proteins, the method comprising: a) providing allylated chromatography beads having an allylated shell layer and an allylated inner core wrapped around by the allylated shell layer; b) inactivating the allylated shell layer of the beads to form a lid of hydrolyzed allyl groups having a thickness of 1-8 .mu.m; c) activating the allylated inner core of the beads. Learn More

A U.S. Patent for "Reusable Aseptic Fluid Couplings" was awarded to Colder Products Company on August 6th, 2019. The present invention is an aseptic fluid coupling system comprising: a first coupling portion comprising: a first valve body defining a first longitudinal axis and a first end port; a first valve member disposed within the first valve body; and a cap that is releasably coupleable to the first valve body, the cap enclosing at least a portion of the first valve body while the cap is coupled to the first valve body; and a second coupling portion configured to releasably couple with the first coupling portion, comprising...  Learn More

A U.S. Patent for "Variable Diameter Bioreactors" was awarded to Lonza on August 6th, 2019. The present invention is a variable diameter bioreactor vessel that can include a first vessel section having a first diameter configured to hold a liquid media and biologic material and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel. In some aspects, the first vessel section can have an aspect ratio of greater than 0.3:1. In some aspects, the second vessel section can have an aspect ratio of greater than 0.3:1. Learn More

A U.S. Patent Application for "Binding Proteins, Including Antibodies, Antibody Derivatives and Antibody Fragments, that Specifically Bind CD154 and Uses Thereof" was published by UCB on August 1st, 2019. The present invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO... Learn More

A U.S. Patent Application for a "Method of Culturing Eukaryotic Cells" was published by Genentech on August 1st, 2019. The present invention is an apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO.sub.2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range. Learn More

A U.S. Patent for "Large Scale Disposable Bioreactor" was awarded to Protalix on July 30th, 2019. The present invention is a reusable, disposable device for culturing plant tissues or cells including a non-rigid container having dimensions and gas exchange ports designed for maintaining oxygen saturation and shear forces suitable for culturing plant tissue or cells in 400 liters or more of culture medium is provided. Also provided are methods for producing a catalytically active human recombinant protein in a plant cell, using the disposable device of one of the embodiments of the instant specification. Learn More

A U.S. Patent for "Ion Exchange Membrane Chromatography" was awarded to Genentech on July 30th, 2019. The present invention are methods of enhancing efficiency of downstream chromatography steps for purification of proteins comprising: (a) passing a composition comprising a polypeptide of interest and various contaminants through an ion exchange membrane, wherein the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pi of the polypeptide to enhance the charge of the polypeptide and a low ionic strength... Learn More

A U.S. Patent Application for a "Method for Packing Chromatography Columns" was published by GE on July 25th, 2019. The present invention discloses a method for packing a plurality of uniform chromatography columns, comprising the steps of: a) providing a plurality of chromatography columns; b) providing a plurality of chromatography resin aliquots; c) packing the chromatography resin aliquots in the chromatography columns to provide a plurality of packed chromatography columns; and d) subjecting the packed chromatography columns to repeated mechanical impacts to provide a plurality of uniform chromatography columns. Learn More

A U.S. Patent Application for "Cell Culture Improvements" was published by AbbVie on July 25th, 2019. The present invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture. Learn More

A U.S. Patent Application for a "Computer Implemented Method for Creating a Fermentation Model" was published by Bayer on July 25th, 2019. The present invention is a computer-implemented method for model-based estimation of the state of a bioreaction with an organism in a bioreactor comprising: creating a model of a bioreaction with an organism, said model including a matrix L, kinetics of macroreactions and model parameters of calculated values, which comprises the following steps: a. defining selected metabolic pathways of the organism, their properties of stoichiometry and reversibility as background knowledge and calculating... Learn More

A U.S. Patent for a "Dual Wavelength Raman Probe with Spectral Concatenation of Data Filtration Systems" was awarded to Innovative Phototonic Solutions on July 23rd, 2019. The present invention is a compact dual-wavelength Raman probe using two laser sources each providing Raman excitation light at a different wavelength is disclosed causing Raman scattering in a fingerprint region associated with one excitation wavelength and causing Raman scattering in a stretch region, which are detected by the same detector array. Learn More

A U.S. Patent for "Perfusion Filtration Systems" was awarded to Artemis Biosystems on July 23rd, 2019. The present invention is a method of filtering a cell culture media comprising passing a cell culture media comprising mammalian cells and a virus through a plurality of tubular porous membranes of a filter elements enclosed within a casing, wherein each tubular porous membrane filter element comprises a plurality of sintered tubular ultra-high-molecular-weight polyethylene (UHMWPE) porous membranes, wherein at least 95% of the pores in each of the plurality of tubular porous membranes are between 5 .mu.m and -15 .mu.m in size... Learn More

A U.S. Patent Application for an "Aseptic Bioreactor Sampling System" was published by Trizell on July 18th, 2019. The present invention is an adherent cell culture bioreactor comprising: a container having an interior for containing liquid cell culture media and a solid support for adherent cell culture, the container interior in flowable communication with a first tube and a second tube, each of said tubes comprising an intake end in flowable communication with the container interior, and an output flush end and an output sample end, whereby liquid cell culture media can flow from the container interior into the intake end of the tube... Learn More

A U.S. Patent Application for "A Process for Degrading Plastic Products" was published by Carbios on July 18th, 2019. The present invention relates to processes for degrading plastic products and the uses thereof. The processes of the invention particularly comprise a step of amorphizing a plastic product prior to a step of depolymerization. The processes of the invention are particularly useful for degrading a plastic product comprising polyethylene terephthalate and/or polylactic acid. The invention also relates to a method of producing monomers and/or oligomers from a plastic product comprising at least one polyester... Learn More

A U.S. Patent for "Pharmaceutical Glass Packaging Assuring Pharmaceutical Sterility" was awarded to Corning on July 16th, 2019.  The present invention is a sterile glass pharmaceutical container or vessel such as, but not limited to, vials for holding pharmaceutical products or vaccines in a hermetic and/or sterile state. The sterile glass pharmaceutical container undergoes a strengthening process that produces compression at the surface and tension within the container wall. The strengthening process is designed such that the tension within the wall is great enough to ensure catastrophic failure of the pharmaceutical container, thus rendering the product unusable... Learn More

A U.S. Patent for "Apparatus and Methods for Aseptic Fluid Interconnects" was awarded to ERBI Biosystems on July 16th, 2019.  The present invention provides apparatus and methods for making multiple aseptic fluid interconnections in parallel with an integral clamping mechanism and elastomeric fluid sealing gasket to provide an initial fluid tight seal while removing sealing tape tabs and a final fluid tight seal after sealing tape tabs are removed. The clamping mechanism comprises a hinge coupling and a first set of snap-fit locks to maintain the initial fluid tight seal and a second set of snap-fit locks to maintain the final fluid tight seal. Learn More

A U.S. Patent for "Processes for Filtering Liquids Using Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems with Recirculation of Retentate" was awarded to MilliporeSigma on July 16th, 2019. The present invention is a method of filtering a liquid feed, comprising: a) passing a liquid feed through a single pass tangential flow filtration (SPTFF) system that comprises: a plurality of stacked filtration modules that are fluidly connected, each filtration module comprising: a single manifold segment comprising a first manifold for receiving and carrying the feed into the filtration module, a second manifold for receiving and carrying retentate. Learn More 

A U.S. Patent Application for "Perfusion Bioreactor Bag Assemblies" was published by Juno Therapeutics on July 11th, 2019.  The present invention is a bioreactor bag assembly that can minimize the amount of additional connections/adaptations made to the bioreactor bag before the bioreactor bag can be used for cell cultivation, thereby reducing the risk of contamination. The bioreactor bag assemblies disclosed herein can include a pre-assembled waste bag connection and pre-assembled tubing arrangements so that the cell media and/or the cell source can be immediately welded to the pre-assembled tubing arrangements. Learn More

A U.S. Patent for a "Horizontally Rocked Bioreactor System" was awarded to Bioreactor Sciences on July 9th, 2019. The present invention is a bioreactor system, comprising: a vessel assembly comprising: a tube positioned to lie along a longitudinal axis, the tube having ends; a baffle extending within the tube, the baffle extending along and contacting an inner wall of the tube along the longitudinal axis and extending to and contacting the ends of the tube, wherein a ratio of a major surface area of the baffle to a central cross-sectional area of the tube along the longitudinal axis is greater than about 0.45 and less than about 0.90...  Learn More

A U.S. Patent for a "Magnetophoresis System for Separation of Biological Particles" was awarded to Pablo Sanchez on July 9th, 2019.  The present invention is an apparatus for analyzing magnetically functionalized particles in a sample comprising: a chamber containing the magnetically functionalized particles in the sample; an analytic instrument communicating with the chamber to receive the magnetically functionalized particles in the sample for analysis; a magnetizable collection structure within the chamber for collecting magnetically functionalized particles from the sample.  Learn More

A U.S. Patent for "Systems and Methods for Adaptive Non-Linear Control of Process Systems" was awarded to Kyle Hunte on July 9th, 2019.  The present invention provides systems and methods for generating an adaptive nonlinear controller and utilizing the adaptive nonlinear controller to regulate the operation of nonlinear process systems. In particular, a method is provided for generating a control model by defining an objective function utilizing a target function that specifies the desired response of the system and a state-space model representing the dynamics of the non-linear system. Learn More

A U.S. Patent for a "Process for Reducing Subvisible Particles in a Pharmaceutical Formulation" was awarded to Regeneron on July 9th, 2019. The present invention provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like. Learn More

A U.S. Patent Application for an "Air Purification System" was published by AWE Solutions on July 4th, 2019.  The present invention is a system and process for purifying air. The system includes a housing and a plurality of inner and outer chambers. A solution of water and a biological reagent is configured to flow around the inner and outer walls of the inner and outer chambers while air is passed adjacent to this fluid flow. This causes an interaction between the air and the fluid solution to cleanse the air. The air is then discharged from the chamber. Learn More

A U.S. Patent Application for "Protein Purification"  was published by UCB on July 4th, 2019.  The present invention relates to a process for purification of a protein comprising a semi-continuous chromatography step whereby the flow-through is collected and re-loaded onto the chromatography matrix. Comprising the steps of a) in an operational chromatography cycle loading a first volume of a mixture containing the protein of interest from a first container to a chromatography matrix operated such that the protein binds to the chromatography matrix until 40% to 100% of the static binding capacity of the chromatography matrix is reached... Learn More

A U.S. Patent for "Processes for Starting Up and Operating Deep Tank Anaerobic Fermentation Reactors for Making Oxygenated Organic Compound from Carbon Monoxide and Hydrogen" was awarded to Synata on July 2nd, 2019. The present invention is a process for starting up and operating anaerobic, deep tank fermentation reactors including a process for anaerobic bioconversion of a gas substrate comprising carbon monoxide, hydrogen, and carbon dioxide in a reactor by contact of the gas substrate with an aqueous menstruum containing microorganisms suitable for converting the gas substrate to an oxygenated organic compound in the reactor. Learn More

A U.S. Patent Application for "Antibody Drug Conjugates" was published by Novartis on June 27th, 2019. The present invention discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents. Learn More

A U.S. Patent Application for a "Method for Producing Recombinant Protein" was published by Spiber on June 27th, 2019. The present invention relates to a method for production of a recombinant protein using recombinant cells that express the recombinant protein under the control of an inducible promoter, the method including continuous culturing with addition of fresh culture medium to a portion of the culture solution in which the recombinant cells have been grown, wherein the recombinant cells whose expression of the recombinant protein has been induced are not reused. Learn More

A U.S. Patent Application for a "Method for Purification of Viruses or Virus Like Particles Using a Crosslinked Cellulose Hydrate Membrane" was published by Sartorius on June 27th, 2019. The present invention is a method for purifying viruses or virus-like particles from a solution, comprising the following steps: a) providing a mixture M composed of a solution A, which contains the viruses or the virus-like particles to be purified and impurities, and a solution B, which contains a polyalkylene glycol having two or three carbon atoms in the repeat unit, d) loading a crosslinked cellulose hydrate membrane with the mixture M from step... LEARN MORE

A U.S. Patent for a "Solventless Extraction Process" was awarded to DSM on June 25th, 2019. The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from micro-organisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained. Learn More

A U.S. Patent for "Conditionally Active Biological Proteins" was awarded to BioAtla on June 25th, 2019. The present invention is a method of preparing a conditionally active biological protein, the method comprising steps of: i) evolving the DNA which encodes a parent biological protein using one or more evolutionary techniques to create mutant DNAs; ii) expressing the mutant DNAs to obtain mutant biological proteins; iii) subjecting the mutant biological proteins to an assay under a first physiological condition selected from physiological conditions of a first location selected from the group. Learn More

A U.S. Patent Application for "Wireless Sensor Information Monitoring" was published by Lonza on June 20th, 2019. The present invention is a system, apparatus, and method for continuously monitoring data output from a wireless sensor on a mesh network at a frequency higher than mesh formation/propagation. For example, the system may include a wireless gateway, an amplifier coupled to the wireless gateway, a first antenna coupled to the amplifier, a second antenna coupled to the amplifier, and a wireless sensor. The wireless sensor may be a wireless temperature sensor configured to monitor the temperature of a cryopreserved material product. Learn More

A U.S. Patent Application for "Packed Bed Emulsification" was published by GE on June 20th, 2019. The present invention is a system for the production of polysaccharide droplets from a water-in-oil emulsion comprising, at least one chamber comprising an inlet side connectable to a source of water-in-oil emulsion containing droplets of an aqueous solution of a polysaccharide in an oil-based continuous phase, an outlet side, a packed bed of beads between the inlet side and the outlet side, and flow-producing means for providing a flow of water-in-oil emulsion through the packed bed to an outlet port, wherein the beads are hydrophilic beads. Learn More

A U.S. Patent for an "Apparatus, Systems and Methods for Growing Microorganisms" was awarded to Locus on June 18th, 2019. The present invention is a fermentation system that includes a fermentation tank, a plurality of sensors operable to measure a plurality of fermentation system parameters, a plurality of mechanisms operable to control the fermentation system parameters, and a controller in electronic communication with the sensors and with the mechanisms. The controller includes a memory, a receiver circuit, a transmitting circuit, and a control circuit. The memory stores a plurality of recipes each defining user operating instructions and parameter settings. Learn More

A U.S. Patent for "High Efficiency Continuous Countercurrent Tangential Chromatography" was awarded to Chromatan on June 18th, 2019. The present invention is a system, module and method for continuous or batch single-pass countercurrent tangential chromatography for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules. The resin slurry flows in a continuous single pass at steady-state through each module, while corresponding buffers flow countercurrent to the slurry facilitating efficient product and impurity extraction... Learn More

A U.S. Patent Application for "Cell Culture Additives and Their Use for Increased Bioprotein Production from Cells" was published by Air Liquide on June 13th, 2019. The present invention relates to a method of increasing protein biomolecule production in which a) a cell that produces a heterologous protein biomolecule is cultured, and b) an Additive and/or a source of the Additive is added to the culture medium in an amount sufficient to (i) increase a total yield of the heterologous protein biomolecule secreted into the cell culture media and/or (ii) increase a specific cellular productivity of the heterologous protein biomolecule secreted into the cell culture media. Learn More

A U.S. Patent Application for a "Method of Producing a Recombinant Protein" was published by GSK on June 13th, 2019. The present invention relates to a recombinant signal sequence, and a fusion protein comprising the signal sequence and a recombinant protein. Methods of producing the recombinant protein using the recombinant signal sequence are described. In particular, the recombinant signal sequence provides a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein. Learn More

A U.S. Patent for a "Method for Producing a Product in a Continuous Cell Culture Fermentation Process"  was awarded to AGC Biologics on June 11th, 2019. The present invention is a method of producing a product selected from a biopolymer expressed by a cell, an intracellular or extracellular product produced by a cell or microorganism, a periplasmatic product produced by a cell or microorganism, a cell or a microorganism in a bioreactor in a chemostat fermentation process, wherein said bioreactor comprises: i) a first outlet having a separation device allowing impurities with a size below the size of the product, and medium to be removed... Learn More

A U.S. Patent Application for "End-to-End Cell Therapy Automation" was published by Lonza on June 6th, 2019. The present invention is a method for automated production of a genetically modified immune cell culture, the method comprising: (a) activating an immune cell culture with an activation reagent to produce an activated immune cell culture; (b) transducing the activated immune cell culture with a vector, to produce a transduced immune cell culture; (c) expanding the transduced immune cell culture; (d) concentrating the expanded immune cell culture of (c); and (e) harvesting the concentrated immune cell culture of (d)... Learn More

A U.S. Patent Application for a "Cell Retention Device and Method" was published by Boehringer Ingelheim on June 6th, 2019. The present invention relates to a cell retention device and method for use in a perfusion cell culture system where the cell retention device includes a hollow-fiber filter having an average pore size ranging from about 0.5 to about 20 .mu.m and having the ability to operate under perfusion cell culture conditions for up to 35 days without being clogged or losing its product sieving ability by more than 20%. Learn More

A U.S. Patent for "Aseptic Coupling Devices" was awarded to Colder Products Company on June 4th, 2019. The present invention is an aseptic coupling arrangement includes a first coupling device and a second aseptic coupling device. In one example, the first and second coupling devices are substantially similar, each having a main body having a front face and a fluid passageway therethrough. A first connecting feature on the main body of each coupling device may be provided for aligning and coupling the aseptic devices together. Each coupling device may also include a sealing member received in the main body and a membrane... Learn More

A U.S. Patent for "Fluid Manifold Systems" was awarded to Thermo Fisher on June 4th, 2019. The present invention is a fluid manifold system that includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold. Learn More

A U.S. Patent for "Filter Systems for Separating Microcarriers from Cell Culture Solutions" was awarded to Thermo Fisher on May 28th , 2019. The present invention is a filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber... Learn More

A U.S. Patent for a "Regulatable Promoter" was awarded to Lonza on May 28th, 2019. The present invention is a method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising a series of steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate or at least 15% as compared to the native pGAP promoter... Learn More

A U.S. Patent for a "Method of Removing DNA from Biotechnological Products" was awarded to BASF on May 28th, 2019. The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or biotransformation, comprising treating the sample with a combination of increased temperature and low pH. It also relates to a method for releasing DNA from a microbial cell, comprising incubating the microbial cell at a temperature of 45.degree. C. to 55.degree. C. for two to ten hours. Finally, the present invention provides a method for producing a product, comprising a step of releasing DNA from a microbial cell and degrading said DNA. Learn More

A U.S. Patent for a "High-Cell Density Fed-Batch Fermentation Process for Producing Recombinant Protein" was awarded to Pfizer on May 28th, 2019. The present invention includes methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions for use in the methods of the present invention, are provided. Learn More

A U.S. Patent Application for an "Automated Bioprocess Development" was awarded to TAP on May 23rd, 2019. The present invention is a method for automating process development in a bioprocessing environment. The method comprising: executing a first experiment run according to a set of parameters; retrieving a first real-time set of data of the experiment nm while the experiment run is being executed; retrieving a second real-time set of data of an experiment run being executed in parallel, analysing the retrieved first real-time set of data and the second real-time set of data to determine an adjusted set of parameters; and, modifying, based on the analysis... Learn More

A U.S. Patent for a "Bioreactor with Condenser" was awarded to Sartorius Stedim on May 21st, 2019. The present invention is a bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser. Learn More

A U.S. Patent for a "Computer-Implemented Method for Creating a Fermentation Model" was awarded to Bayer on May 21st, 2019. The present invention is a computer-implemented method for process control of a bioreaction with an organism comprising: creating a model of a bioreaction with an organism, said model including a matrix L, kinetics of macroreactions and model parameters of calculated values, which comprises the following steps: a. defining selected metabolic pathways of the organism, their properties of stoichiometry and reversibility as background knowledge and calculating elementary modes from this input; b. combining the elementary modes. Learn More

A U.S. Patent for a "Flexible Manufacturing System" was awarded to Xoma on May 21st, 2019. The present invention is a unitary structure adapted to be disposed within a housing, comprising: at least one controlled air, sealable, sterilizable cleanroom having an entry point and an exit point; a cleanroom entry portion coupled to and selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point; a cleanroom exit portion coupled to and selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow... Learn More

A U.S. Patent Application for "Particles for Use in Acoustic Standing Wave Processes" was published by FloDesign Sonics on May 16th, 2019. The present invention is a method for concentrating particles in a primary fluid at a first location, comprising: flowing a fluid mixture comprising the particles and the primary fluid through an acoustophoretic device that comprises: an acoustic chamber through which the fluid mixture flows; and an ultrasonic transducer including a piezoelectric material that can be driven to create an acoustic wave in the acoustic chamber; and driving the ultrasonic transducer to create the acoustic wave; wherein the acoustic wave concentrates the particles at the first location. Learn More

A U.S. Patent Application for " Automated Control of Cell Culture Using Raman Spectroscopy"  was published by Lonza on May 16th, 2019. The present invention provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different cell lines producing different mAbs. Developed predictive models, qualified using an independent cell line not used in calibration... Learn More

A U.S. Patent for "Methods of Reducing Level of One or More Impurities in a Sample During Protein Purification" was awarded to MilliporeSigma on May 14th, 2019. The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product. Learn More

A U.S. Patent for a "Syringe Containing Stable Aqueous Formulations of Adalimumab" was awarded to Coherus Biosciences on May 14th, 2019. The present invention relates to aqueous pharmaceutical compositions suitable for long-term storage of adalimumab (including antibody proteins considered or intended as "biosimilar" or "bio-better" variants of commercially available adalimumab), methods of manufacture of the compositions, methods of their administration, and kits containing the same. Learn More

A U.S. Patent for a "High Pressure Bioreactor" was awarded to Carnegie Institution on May 7th, 2019. The present invention relates generally to an integrated system, apparatus and method that allows for the continuous culturing of microorganisms under high pressure conditions and at a wide range of temperatures. More specifically, the system is configured to be gas tight and operate under aerobic or anaerobic conditions. The system is also configured to permit periodic sampling of the incubated organisms under such conditions with minimal physical and chemical disturbance inside the reactor and minimal impacts of shear forces on the collected biomass. Learn More

A U.S. Patent for "Recipient for Cell Cultivation" was awarded to Pall on May 7th, 2019. The present invention is a system for cell cultivation, comprising a recipient having an inner compartment for cell growth, the recipient comprising: an outer tubular wall extending in a longitudinal direction, the outer tubular wall delimiting an outer boundary of the inner compartment in a radial direction; first and second ends delimiting the inner compartment at the first outer end and the second outer end of the outer tubular wall; a packing in the inner compartment comprising a fiber matrix... Learn More

A U.S. Patent for " Highly Concentrated Pharmaceutical Formulations"  was awarded to Genentech  on May 7th, 2019. The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab<CD20>, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-CD20 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. Learn More

A U.S. Patent for " Cell Culture Additives and Their Use for Increased Bioprotein Production from Cells"  was awarded to Air Liquide  on May 7th, 2019. The present invention relates to a method of increasing protein biomolecule production in which a) a cell that produces a heterologous protein biomolecule is cultured, and b) an Additive and/or a source of the Additive is added to the culture medium in an amount sufficient to (i) increase a total yield of the heterologous protein biomolecule secreted into the cell culture media and/or (ii) increase a specific cellular productivity of the heterologous protein biomolecule secreted into the cell culture media. Learn More

A U.S. Patent for an " Apparatus, Method and System for Recording at Least One Variable During a Biological and Chemical Process"  was awarded to PreSens  on May 7th, 2019. The present invention is an apparatus, a method and a system for the parallelized recording of at least one variable during a biological/chemical process are disclosed. A matrix, which has at least one container and which can be positioned on a measurement carrier, is provided to accommodate the liquid samples. A measuring unit, which comprises a controllable radiation source for electromagnetic radiation and at least one sensor for detecting electromagnetic radiation, is fixedly disposed in or on the measurement carrier. Learn More

A U.S. Patent Application for "Direct Selection of Cells Expressing High Levels of Heteromeric Proteins Using Glutamine Synthetase Intragenic Complementation Vectors" was published by Amgen on May 2nd, 2019. The present invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides. Learn More

A U.S. Patent Application for "Compositions and Methods for Regulating Cell Osmolarity" was published by Genentech on May 2nd, 2019. The present invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE). Learn More

A U.S. Patent for " Abrasion Resistant Film for Biocontainers"  was published by MilliporeSigma on April 30th, 2019. The present invention is a biocontainer film enhanced with an abrasion resistant or "cut-proof" substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. Learn More

A U.S. Patent Application for " Cation Exchange Chromatography Methods"  was published by Bristol- Myers Squibb  on April 25th, 2019. The present invention provides improved methods of protein purification using CEX chromatography. Such methods generally comprise the steps of: contacting a protein of interest (e.g., an antibody) with a cation exchange resin at a first pH, that is less than the pI of the most acidic isoform of the protein of interest, such that the protein of interest binds to the resin; washing the cation exchange resin at a second pH that is greater than the first pH, but less than the p1 of the most acidic isoform of the protein of interest... Learn More

A U.S. Patent Application for a " Method and Apparatus for Quantifying Solutions Comprised of Multiple Analytes"  was published by Finesse on April 25th, 2019. The present invention is a multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer. Learn More

A U.S. Patent Application for " Inhibition of Protein Degradation for Improved Production" was published by Lonza  on April 25th , 2019.  The present invention discloses methods and compositions useful for evaluating, selecting, identifying, or making a cell or cell line that has improved production capacity for generating higher yields of products and/or improved capacity to produce higher quality products. Products, as described herein, can include a polypeptide that is endogenously expressed by the cell, a recombinant polypeptide that is not endogenously expressed, or a non-naturally occurring recombinant polypeptide. Learn More

A U.S. Patent for a " Magnetic Mixing System and Method" was awarded to Sani-Tech West on April 23rd , 2019. The present invention is a mixing system typically for use in a container for mixing its contents, the mixing system including a cap unit, an extension unit and a magnetic mixing unit that is attached to the cap unit by the extension unit. The magnetic mixing unit can be folded to permit insertion and/or removal of the system via a mouth of the container. The extension unit and magnetic mixing unit connect via a hinge formed by upper and lower hinge portions that meet at a pivot point.  Learn More

A U.S. Patent for a " Chromatography Method"  w as awarded to GE on April 23rd , 2019. The present invention is a method for purification of immunoglobulin containing proteins or parts thereof, from contaminants that are larger than immunoglobulin containing proteins, the method comprising: a) contacting an immunoglobulin containing sample with agarose chromatography beads comprising a lid consisting of agarose modified with hydrolyzed allyl groups and having a thickness of 1-8 .mu.m with a defined pore size and an inner core of defined pore size consisting of agarose modified with an affinity ligand. Learn More

A U.S. Patent for a " Micro Titre Plate"  w as awarded to GE on April 23rd , 2019. The present invention is a micro titre plate comprising a number of wells disposed in a plurality of columns and rows, the wells being filled with the same type of separation matrix, wherein the separation matrix in the wells of the plate has a series of volumes V.sub.1, V.sub.2, . . . V.sub.n distributed according to a specific pattern that does not obey logarithmic or a single degree freedom linear relationship and same separation matrix volume is provided in all the wells of either the same column or the same row in the plate...  Learn More

A U.S. Patent Application for " In Situ Raman Spectroscopy Systems and Methods for Controlling Process Variables in Cell Cultures" w as published by Regeneron on April 18th, 2019. The present invention provides in situ Raman spectroscopy methods and systems for monitoring and controlling one or more process variables in a bioreactor cell culture in order to improve product quality and consistency. The methods and systems utilize in situ Raman spectroscopy and chemometric modeling techniques for real-time assessments of cell cultures, combined with signal processing techniques, for precise continuous feedback and model predictive control... Learn More

A U.S. Patent for a " Cost-Effective Raman Probe Assembly for Single-Use Bioreactor Vessels"  was awarded to Kaiser Optical  on April 16th, 2019. The present invention consists of systems and methods used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. Learn More

A U.S. Patent for " Stackable Chromatography Column Modules and Flow Control Blocks" was awarded to  GE  on April 16th, 2019. The present invention discloses a flow control block for a stack of chromatography column modules, as well as a stack of chromatography modules comprising at least one flow control block. The flow control block is in a first position or configuration capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series. Learn More

A U.S. Patent Application for "Monoclonal Anti-IL-1RACP Antibodies" was published by MAB Discovery on April 11th, 2019. The present invention is a monoclonal antibody that specifically binds the interleukin 1 receptor type 1, or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected... Learn More

A U.S. Patent for " Particle Analyzing Systems and Methods Using Acoustic Radiation Pressure" was awared to Thermo Fisher  on April 9th, 2019.  The present invention is a particle analyzing system, comprising: a flow cell configured to receive a sample stream that comprises a plurality of particles; an acoustic device configured to acoustically focus at least some of the particles within the flow cell; a fluidics system configured to hydrodynamically focus at least some of the plurality of particles within the flow cell; a controller configured to automate an aspect of the particle analyzing system operation; and, a monitor configured to monitor at least some of the plurality of particles... Learn More

A U.S. Patent for a " Method for Retrovirus Removal"  was published by MilliporeSigma on April 9th, 2019. The present invention is a method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat. Learn More

A U.S. Patent for a " Bioreactor Arrangement, Shaking Device and Method for Irradiating a Medium in a Bioreactor"  was published by Sartorius Stedim on April 9th, 2019. The present invention is a bioreactor arrangement that has a bioreactor and an illuminating body for illuminating a medium in a reactor interior. The illuminating body has at least one emission surface via which light, reflected by at least one end surface into the reactor interior, is emitted. The bioreactor is formed as a container having a transparent wall. A shaking device has a reactor holder that can be in oscillated, for a bioreactor with a transparent wall. Learn More

A U.S. Patent Application for " Single-Pass Filtration Systems and Processes"  was published by MilliporeSigma on April 4th, 2019. The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass TFF assemblies, scalable single-pass TFF assemblies and adaptable modular single-pass TFF assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass TFF assembly and for cleaning a TFF assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass TFF assembly. Learn More

A U.S. Patent for a " Flow Regulator as well as Method for Setting a Predefinable Volume Flow"  was awarded to Levitronix on April 2nd, 2019. The present invention is a flow regulator that includes a first sensor determining a first actual value of a first flow parameter of the fluid, a pre-pressure regulator setting a predefinable pre-pressure at a pre-pressure outlet of the pre-pressure regulator, and a regulating pump. The fluid is capable of being supplied to the pre-pressure regulator at a plant pressure in an operating state via an inflow line and a pre-pressure inlet and capable of being conducted further to the regulating pump at the pre-pressure. Learn More

A U.S. Patent for a " Fluid Transfer Device"  was awarded to MilliporeSigma on April 2nd, 2019. The present invention is a disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger. Learn More