Bioprocess Alert

This video, which has 19,000+ views,  demonstrates why you cannot use geometric scale-up of a batch reactor with heat transfer.

This video, part 3 of a 4 part series, provides insights into the principles and practices associated with bioprocess validation.

This video, which has 160,000+ views, provides the principles and practices associated with aseptic gowning for work in a cleanroom.

This video provides insight into the reality of viral contamination and serves as an introduction to the principles and practices associated with viral safety.

This video, which has 20,000+ views, explains cell culture media and the components of culture media for cell growth.

This video, which has 8,500+ views, explains several methods for the separation of proteins.

This video, which has 69,000+ views, provides a highly informative explanation of the differences between aerobic and anaerobic processes.

This video, which has 123,000+ views, utilizes animation and narration to explain the various protein structures and the practice of folding.

This video, which has 320,000+ views, utilizes animation and narration to explain how gel electrophoresis functions to separate molecules by size.

This video, which has 77,000+ views, is hosted by Amgen's Sean Harper and discusses the future of biotechnology.

This video, which has 180,000+ views, provides a highly informative introduction to the principles and practices associated with infrared spectroscopy.

This video, which has 221,000 views, provides both an illustration and narration explaining the operation of most common industrial valves and their associated features as well as benefits.

This video, which has 18,000+ views, provides a highly informative overview of the operating principles behind peristaltic pumps.

This video, which has 70,000+ views, provides an introduction to the principles and practices associated with buffer solutions.

This video, which has 4,500+ views, explains the role of a legend in describing a process.

This video, which has 59,000+ views, explains manual processes versus automated processes.

This video, which has 3,000+ views, explains cell culture best practices and their role in improving reproducibility and reliability when culturing cells.

This video, which has 92,000+ views, utilizes a narrative coupled with animation to explain the principles of Raman Spectroscopy.

This video on Protein Purification provides insight into the process and tools that scientists and engineers use to explore proteins.

This video, which has 165,000+ views, provides an informative overview of the principles at work in four types of flowmeters; Mechanical, Magnetic, Vortex and Ultrasonic.

This video, which has 2,300+ views in its first 24 hours online, explains Ethernet/IP. It explains both what it is, and perhaps just as importantly, what it is not.

This video, which has 157,000+ views, explains the dissolution of a solute in a solution.

This video explains the principles and practices associated with aeration and agitation in bioprocessing applications.

This video, which has 2.4+ million views, delivers an informative view of what constitutes a cell.

This video, which has 320,000+ views, explains the process of anaerobic respiration.

This video, which has 15,000+ views, provides a summary of quantitative and qualitative validation cleaning techniques for FDA regulated applications. It includes a Q&A session that provides further insights.

This video, which has 684,000+ views, discusses the basics of steam hammer and its effects.

This video, which has 498,000+ views, discusses the basics of fluid cavitation and its effects.

This video, which has 99,000+ views, explains the structural components and functionalities of a pressure relief valve.

This video, which has 197,000+ views, provides an informal yet informative overview of amino acids.

Protein folding is the continual and universal process whereby the long, coiled strings of amino acids that make up proteins in all living things fold into more complex three-dimensional structures. By understanding how proteins fold, and what structures they are likely to assume in their final form, researchers are then able to move closer to predicting their function.

Baffles are internals, generally flat plates, used in agitated vessels to optimize and stabilize the mixing flow pattern and minimize variation in agitator power draw. Baffle recommendations are part of the agitator vendor's scope although the baffles are designed and fabricated by others. Proper baffle implementation dramatically impacts process results. Learn More

In deciding which single-use platform to choose, reliability and robustness are fundamental requirements. Beyond process performance, it is important to consider how control systems and automation come into play, how easy it is to implement the platform, and if the design is flexible enough to support varying production volumes.

One of the primary safeguards that life science companies use to help prevent contamination in cleanroom operations is Gowning.
Gowning is basically putting on clothing -- in this case layers of specially designed garments, covers, masks and gloves -- that isolates your body from the clean room environment.

Gowning is more involved than just slipping on a coverall and going to work. Gowning is itself a process, with carefully sequenced steps to ensure that your body is fully covered, and that the protective garb remains free of contamination.

This video, which has 133,000+ views, demonstrates the top-down approach for both general and aseptic gowning.

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Original Publication Date:
04/05/2013

This video, which has 85,000+ views, is the second in a series of three videos depicting the major stages of industrial-scale bioprocessing: fermentation, separation/recovery, and purification. This video describes the process by which a biological product—in this case, molecules of Green Fluorescent Protein (GFP)—is recovered from host e coli cells. The steps of this process are, in very basic terms: (1) separation of cell solids from the broth, (2) disruption of those host cells to release the product contained in them, and (3) isolation of the product through removal of cell debris and other impurities. Tools used to perform these steps include centrifuges, cell disrupters and microfilters.

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Original Publication Date:
10/10/2013

This video, which has 94,000+ views, is the third in a series of three videos depicting the major stages of industrial-scale fermentation: fermentation, separation/recovery, and purification. This program describes the process by which a biological product—in this case, a pure, concentrated solution of Green Fluorescent Protein (GFP)—is derived from clarified lysate. This is accomplished through multiple variations of two basic procedures: chromatography and filtration.

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Original Publication Date:
10/30/2013

In this week's Two Minute Tuesday video tutorial we will examine the impact of pH on cell culture in bioreactors. This video will detail the importance of pH for optimal cell growth within a bioreactor, what factors can impact pH and how to control the pH of the growth media during production.

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The-Impact-of-pH-on-Cell-Culture-in-Bioreactors-Two-Minute-Tuesday-Video.mp4
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Original Publication Date:
07/18/2018

Understanding the impact of aeration and thus the dissolution of oxygen into the bioreactor growth media for uptake by the production cell line is paramount for success in bioprocessing. Watch the following Two Minute Tuesday technical training video for an overview of the concepts and important considerations for aeration in bioreactor operations.

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The-Impact-of-Aeration-on-Cell-Culture-in-Bioreactors2C-Part-1-Two-Minute-Tuesday-Video.mp4
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Original Publication Date:
07/18/2018