The objective of this mini-review is to provide an overview of: the history of bioprocess affinity chromatography, the current state of platform processes based on affinity capture steps, the maturing field of custom developed bioprocess affinity resins, the advantages of affinity capture based downstream processing in comparison to other forms of chromatography, and the future direction for bioprocess scale affinity chromatography. The use of affinity chromatography can result in economic advantages by enabling the standardization of process development and the manufacturing processes and the use of continuous operations in flexible multiproduct production suites. Learn More