A U.S. Patent Application for “Multivariate Spectral Analysis and Monitoring for Biomanufacturing” was published by Genzyme on September 5th, 2019. The present invention features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit. Learn More