Stem cell scientists in California who have benefited from a $3 billion state research agency created in 2004, at the height of federal limits on working with cells from human embryos, have long known that it would eventually run out of money. That reality set in last month, when the California Institute for Regenerative Medicine (CIRM) in Oakland announced it is no longer taking grant applications. Ongoing payments for approved projects continue, but scientists are already tightening their belts for a funding gap. They are also contemplating the end of a boom in stem cell research in the state. Learn More