A U.S. Patent for a “Computer-Implemented Method for Creating a Fermentation Model” was awarded to Bayer on May 21st, 2019. The present invention is a computer-implemented method for process control of a bioreaction with an organism comprising: creating a model of a bioreaction with an organism, said model including a matrix L, kinetics of macroreactions and model parameters of calculated values, which comprises the following steps: a. defining selected metabolic pathways of the organism, their properties of stoichiometry and reversibility as background knowledge and calculating elementary modes from this input; b. combining the elementary modes. Learn More