A U.S. Patent for a “High Pressure Bioreactor” was awarded to Carnegie Institution on May 7th, 2019. The present invention relates generally to an integrated system, apparatus and method that allows for the continuous culturing of microorganisms under high pressure conditions and at a wide range of temperatures. More specifically, the system is configured to be gas tight and operate under aerobic or anaerobic conditions. The system is also configured to permit periodic sampling of the incubated organisms under such conditions with minimal physical and chemical disturbance inside the reactor and minimal impacts of shear forces on the collected biomass. Learn More