A U.S. Patent for a ” Chromatography Method”  w as awarded to GE on April 23rd , 2019. The present invention is a method for purification of immunoglobulin containing proteins or parts thereof, from contaminants that are larger than immunoglobulin containing proteins, the method comprising: a) contacting an immunoglobulin containing sample with agarose chromatography beads comprising a lid consisting of agarose modified with hydrolyzed allyl groups and having a thickness of 1-8 .mu.m with a defined pore size and an inner core of defined pore size consisting of agarose modified with an affinity ligand. Learn More