In Situ Raman Spectroscopy Systems and Methods for Controlling Process Variables in Cell Cultures



A U.S. Patent Application for ” In Situ Raman Spectroscopy Systems and Methods for Controlling Process Variables in Cell Cultures” w as published by Regeneron on April 18th, 2019. The present invention provides in situ Raman spectroscopy methods and systems for monitoring and controlling one or more process variables in a bioreactor cell culture in order to improve product quality and consistency. The methods and systems utilize in situ Raman spectroscopy and chemometric modeling techniques for real-time assessments of cell cultures, combined with signal processing techniques, for precise continuous feedback and model predictive control… Learn More