The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality. Single-pass tangential flow filtration (SPTFF) can be used to intensify manufacturing processes to meet these goals. Here, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity. This intensified polishing approach can be linked with upstream steps for a more continuous process which eliminates tankage and hold time, and enables the use of smaller polishing columns to improve productquality at higher throughputs.
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Original Publication Date: 11/10/2017