Evaluate high pressure refolding

  • For our specific manufactured molecular formats on a variety of model proteins
  • Develop experimental approach for fast optimization of process parameters
  • Compare structure, stability, and activity of the protein variants refolded with high pressure vs. conventional methods
  • Identify potential economic benefits of high pressure compared with conventional refolding

Evaluate high pressure for the dissolution of soluble protein aggregates

  • Using process-related aggregates of a relevant model protein
  • Show that solubilized monomers have native structure

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Original Publication Date: 10/26/2016