Increasing process complexity coupled with rising cost pressures and rapidly evolving regulatory requirements makes today’s process development eorts a special challenge. The pressure of achieving faster time-to-market for new and innovative biotechnological products has led to the need to optimize every element of the total development workflow. The following application note illustrates how the DASbox® Mini Bioreactor System combined with the BioBLU® 0.3c single-use vessels supports bioprocess development in human cell culture. Scale-down capabilities were investigated by comparison of 500 mL cultures in a DASGIP® Parallel Bioreactor System with 170 mL cultures in the DASbox using the BioBLU 0.3c single-use vessel.
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Original Publication Date: 06/1/2012