A U.S. Patent for a “Method for the Production of Protein Complexes and Vaccine Compositions Comprising the Same” was awarded to Immunobiology on March 26th, 2019. The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress-inducing stimuli. The invention further extends to the use of heat shock protein complexes produced. Learn More