Chromatography Ligand Comprising Domain C from Staphylococcus Aureus Protein A for Antibody Isolation



A U.S. Patent Application for a “Chromatography Ligand Comprising Domain C from Staphylococcus Aureus Protein A for Antibody Isolation” was published by GE on February 28th, 2019. The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. Learn More