Dana-Farber Researcher Ruled Co-Inventor of Cancer Treatment

A federal judge has ruled that a Dana-Farber Cancer Institute researcher and another scientist are among the inventors of a landmark cancer treatment and will share in six patents worth billions of dollars that had been granted to the researchers' former collaborator. District Court Judge Patti B. Saris ruled that Gordon J. Freeman, a Dana-Farber researcher and Harvard Medical School professor, and Clive Wood will be added to patents granted to Dr. Tasuku Honjo of Kyoto University and a handful of Japanese collaborators. Saris wrote that, after a bench trial, she found that "Dana-Farber has presented clear and convincing evidence that Dr. Freeman and Dr. Wood are joint inventors of the six Honjo patents. Learn More

Just Biotherapeutics Acquired by Evotec for Roughly $90M in Cash

Just Biotherapeutics has announced an agreement to be acquired by German biotech company Evotec for up to $90 million. Founded in 2014 by a group of former Amgen scientists, Evotech is paying all cash for the acquisition, with an unspecified portion of the $90 million price tag contingent upon Just Biotherapeutics reaching certain milestones over the next three years. The acquisition is expected to close in the second half of this year. Just Biotherapeutics has about 90 employees, most of them scientists, working at its facility in Seattle's South Lake Union neighborhood. Learn More

University of Maryland BioPark Unveils Plans for a $200M+ Biotech Building

The University of Maryland BioPark is planning its next building as developer Wexford Science & Technology has revealed plans for a $200-plus million, 10-story, 333,000 sq. ft. office and biotech building at the northwest corner of Martin Luther King Blvd. and W. Baltimore St. The new building is Phase One of a two-phrase project that will redevelop a Poppleton/Hollins Market block that borders Martin Luther King Blvd., W. Baltimore St., W. Fayette St., and N. Fremont Ave. The project site currently includes green spaces, a parking lot, and several open spaces created by demolishing a Chinese carryout restaurant, rowhomes, and a former church. Learn More

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FDA 483s Pile Up in Crackdown on Sartan Manufacturers in India

In line with efforts to assess the impact and sources of the sartan safety scandal, India-based Torrent Pharmaceuticals and Cadila Healthcare separately drew lengthy U.S. FDA Form 483s over, among other issues, failures to thoroughly review unexplained discrepancies. The manufacturing site inspection at Torrent Pharmaceuticals FDA investigators conducted over the course of about a week last month resulted in four inspectional citations, with the 483 largely focusing on that firm's investigations into out-of-specification (OOS) results. The FDA's visit to Cadila Healthcare's site from late April to early May revealed 14 observations of manufacturing deficiencies. Learn More

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Novel, Linked Bioreactor System for Continuous Production of Biologics

A novel, alternative intensified cell culture process comprised of a linked bioreactor system is presented. An N-1 perfusion bioreactor maintained cells in a highly proliferative state and provided a continuous inoculum source to a second bioreactor operating as a continuous-flow stirred-tank reactor (CSTR). An initial study evaluated multiple system steady-states by varying N-1 steady-state viable cell densities, N-1 to CSTR working volume ratios, and CSTR dilution rates. After identifying near optimum system steady-state parameters yielding a relatively high volumetric productivity while efficiently consuming media, a subsequent lab scale experiment...

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Have you heard of an adapter that enables my optical DO probes to be used in my single-use bags?

It took a little digging, but I think I have a couple of products from industry leaders that will enable both your optical dissolved oxygen probes, as well as your conventional pH sensors, to be used with your single-use bags. The beauty of both these products is that they allow you to use sensing solutions that have been proven accurate and reliable in bioprocessing while at the same time fulfilling your need for them to support applications in single-use bags.

Hamilton

Mettler Toledo

Understanding the Role of Dissolved O2 & CO2 on Cell Culture in Bioreactors

This video, which has 10,000+ views, uses narration and animation to explain the role of dissolved oxygen and carbon dioxide on cell culture in bioreactors.

Previous Survey Results
Are you comfortable with the use of predictive modeling to quantify bioprocess indications as bioprocess values?
Please comment on the reason(s). %

Participant Comment
"We don't do enough bioprocess modeling"

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Webinar: Large Scale Intensified Cell Culture Processes

Wednesday, May 22nd, 2019

The BPOG Roadmap describes process intensification as a promising trend in biomanufacturing. In his webinar, Gerben Zijlstra, Global Technology Consultant, gives a practical overview of the latest Sartorius technologies that allow for the intensification of cell culture processes.

Key Takeaways from this Webinar:

  • Insights into novel tools for more efficient development of intensified upstream processes such as the ambr®15 system, ambr®250 HT perfusion, and Rocking Motion (RM) perfusion
  • In-house and customer case studies illustrating the use of the ambr®15 system for clone and media screening under perfusion conditions
  • New manufacturing tools on production scale and case studies etc.

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Surprising Research Result: All Immature Cells Can Develop into Stem Cells

A new study conducted at the University of Copenhagen challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy. Results have just been published in Nature. The surprising findings are the result of a search for understanding of what controls the destiny of intestinal stem cells. By introducing luminescent proteins into the cells researchers could, using advanced microscopy, monitor the development of the individual cells. Learn More

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Particles for Use in Acoustic Standing Wave Processes

A U.S. Patent Application for "Particles for Use in Acoustic Standing Wave Processes" was published by FloDesign Sonics on May 16th, 2019. The present invention is a method for concentrating particles in a primary fluid at a first location, comprising: flowing a fluid mixture comprising the particles and the primary fluid through an acoustophoretic device that comprises: an acoustic chamber through which the fluid mixture flows; and an ultrasonic transducer including a piezoelectric material that can be driven to create an acoustic wave in the acoustic chamber; and driving the ultrasonic transducer to create the acoustic wave; wherein the acoustic wave concentrates the particles at the first location. Learn More

1932 Amelia Earhart Becomes the First Woman to Make a Solo, Nonstop Transatlantic Flight

On this day in 1932, five years to the day that American aviator Charles Lindbergh became the first pilot to accomplish a solo, nonstop flight across the Atlantic Ocean, female aviator Amelia Earhart becomes the first pilot to repeat the feat, landing her plane in Ireland after flying across the North Atlantic. Learn More

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Why Must Artists be Poor?

The arts bring meaning to our lives and spirit to our culture -- so why do we expect artists to struggle to make a living? Hadi Eldebek is working to create a society where artists are valued through an online platform that matches artists with grants and funding opportunities -- so they can focus on their craft instead of their side hustle. Learn More

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Celltrion Makes Public Plans to Invest $33 Billion in Biologics, APIs and AI

Celltion Chairman Seo Jung-jin has announced that the biopharma group will invest roughly $34 billion and create some 110,000 jobs by 2030. These monies will be distributed so as to provide roughly $23 billion for its biopharma business, $4 billion for its APIs business and $7 billion for its U-Healthcare platform business which involves artificial intelligence and medical database services. The stated purpose of which being to build a bio-industrial valley capable of making South Korea the hub of the global biopharma industry. To realize this business plan, Celltrion says it will hire some 2,000 R&D professionals and 8,000 others for its expanded factories. Learn More

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In 2007, Scotland Spent Over $100,000 Changing Their National Slogan

It went from 'The Best Small Country in the World' to the "vibrant" new slogan 'Welcome to Scotland'.  Learn More