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Seamless Integration of Glucose Control Using Raman Spectroscopy in CHO Cell Culture | Aspen Xchange
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In the context of Process Analytical Technologies (PAT) implementation in the biopharmaceutical industry, Quality by Design (QbD) is being developed and widely implemented and used. In upstream processes, one compound of great interest to monitor is glucose, and specifically, being able to control its concentration during the process. Such a monitoring leads to process quality improvement, including glycosylation of the product of interest. In this study, a Raman analyzer has been successfully used to implement a feedback control loop in a CHO cell culture based on glucose concentration. The feedback control loop implied a direct OPC UA connectivity between the analyzer and the bioreactor control system.
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