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Closing the System: Production of Viral Antigen-Presenting Dendritic Cells Eliciting Specific CD8 T Cell Activation in Fluorinated Ethylene Propylene Cell Culture Bags | Aspen Xchange
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Closing the System: Production of Viral Antigen-Presenting Dendritic Cells Eliciting Specific CD8 T Cell Activation in Fluorinated Ethylene Propylene Cell Culture Bags



A major obstacle to anti‐viral and ‐tumor cell vaccination and T cell immunotherapy is the ability to produce dendritic cells (DCs) in a suitable clinical setting. It is imperative to develop closed cell culture systems to accelerate the translation of promising DC‐based cell therapy products to the clinic. The objective of this study was to investigate whether viral antigen‐loaded monocyte‐derived DCs (Mo‐DCs) capable of eliciting specific T cell activa‐ tion can be manufactured in fluorinated ethylene propylene (FEP) bags.
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