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Methods and Compositions Comprising Purified Recombinant Polypeptides | Aspen Xchange
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A U.S. Patent for “Methods and Compositions Comprising Purified Recombinant Polypeptides” was awarded to Genetech on November 3rd, 2020. The present incention is a method of purifying a recombinant antibody produced in Chinese hamster ovary host cells and having phospholipase B-like 2 (PLBL2) levels greater than 100 ng/mg, wherein the method comprises performing a hydrophobic interaction chromatography (HIC) step and provides a purified preparation comprising the recombinant antibody and a residual amount of hamster PLBL2, and wherein the residual amount of hamster PLBL2 is less than 20 ng/mg. 
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