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Practical Aspects of Sample Concentration and Buffer Exchange Utilizing a Miniaturized Tangential Flow Filtration (TFF) System | Aspen Xchange
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Practical Aspects of Sample Concentration and Buffer Exchange Utilizing a Miniaturized Tangential Flow Filtration (TFF) System



Here we present our miniaturized TFF system, one of the smallest device of its kind available, intended specifically for lab-scale purifications. It has the completely recoverable dead volume under one milliliter and can accommodate volumes up to 50 mL if performing diafiltration in the same run, or up to 100 mL if only concentrating. The PULSE TFF System is capable of ultrafiltration rates up to 5 times faster compared to a 15 mL centrifugal device and is completely automated with non-contact liquid sensing, bringing the retentate volume down to the specified setpoint.
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