Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-1.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-1.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-2.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-2.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-3.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-3.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-4.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-4.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-5.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-5.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-6.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-6.php on line 5

Warning: in_array() expects parameter 2 to be array, string given in /home/aspenxadmin/public_html/wp-content/plugins/ajax-search-pro/includes/classes/actions/class-asp-indextable.php on line 156

Warning: get_class() expects parameter 1 to be object, null given in /home/aspenxadmin/public_html/wp-content/plugins/real-media-library/inc/comp/WPML.class.php on line 32
Filtration | Aspen Xchange
Warning: Use of undefined constant full - assumed 'full' (this will throw an Error in a future version of PHP) in /home/aspenxadmin/public_html/wp-content/themes/magzilla/header.php on line 64


Wide‐Surface Pore Microfiltration Membrane Drastically Improves Sieving Decay in TFF‐Based Perfusion Cell Culture and Streamline Chromatography Integration for Continuous Bioprocessing

Although several compelling benefits for bioprocess intensification have been reported, the need for a streamlined integration of perfusion cultures with capture chromatography still remains unmet. Here, a robust solution is established by conducting tangential flow filtration‐based perfusion with a wide‐surface pore microfiltration membrane. The resulting integrated continuous bioprocess demonstrated negligible retention of antibody, DNA, and host cell proteins in the bioreactor with average sieving coefficients of 98 ± 1%, 124 ± 28%, and 109 ± 27%, respectively. Further discussion regarding the potential membrane fouling mechanisms is also provided by comparing two membranes with different surface pore structures and the same hollow fiber length, total membrane area, and chemistry.
Learn More