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Process for Manufacturing Factor VIII Having an Improved Ratio of FVIII:C/FVIII/AG | Aspen Xchange
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A U.S. Patent for a “Process for Manufacturing Factor VIII Having an Improved Ratio of FVIII:C/FVIII/AG” was awarded to Octapharma on November 3rd, 2020. The present invention is a process for manufacturing of a Factor VIII product having a ratio of FVIII:C/FVIII:Ag of at least 0.7 in the Factor VIII product by using chromatography wherein at least one chromatographic step is performed by means of employing; An affinity chromatography resin having an affinity for specifically binding of Factor VIII which is effected by an affinity ligand which is immobilised on the affinity chromatography resin, said affinity ligand is a 13 kD yeast derived Fab antibody fragment directed to the Factor VIII molecule. An anionic chromatography resin. A size exclusion resin…
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