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Meeting Challenging Market Demands: Can Traditional Column Chromatography Be Eliminated? | Aspen Xchange
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Thursday, December 3rd, 2020

Xindao Mao, Product Manager Chromatography Systems

Process intensification is one possibility to meet these goals. In the past, the focus of process intensification was mainly on the upstream side, which pushed the bottlenecks into the downstream area. An important step in DSP is mAb capture. Here the mAb is very specifically captured by a protein A ligand, resulting in >95% of purity. For several decades the default technology has been the use of packed bed column chromatography and diffusion-limited affinity resins. This is a significant pain point in the downstream process, as the flow rate limitations and subsequent underutilization of these resins present considerable investments and process risks for drug manufacturers. Rapid Cycling Chromatography (RCC) is one way to overcome the limitations of processes based on protein A resins.

In this exciting webinar, we will present how Sartorius addresses the needs for downstream process intensification with a newly developed Protein A membrane and an optimized RCC skid.
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