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Online Monitoring of Viable Cell Concentrations in Small Bioreactors | Aspen Xchange
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The production of monoclonal antibodies with a mammalian cell culture process is a complex and challenging step in modern medicine to achieve final pharmaceutical products such as vaccines. Viable cell concentration (VCC) is one of the most important key performance indicator during mammalian cell cultivation mainly measured offline. According to FDA ́s PAT initiative, process monitoring and control should be applied to gain process understanding and improve control of process parameters leading to high product quality. Thus, the implementation of an online capacitance probe in a small scale bioreactor is demonstrated.
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