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Current Challenges with Cell Culture Scale-Up for Biologics Production | Aspen Xchange
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In the past decade, upstream scale-up of mammalian cell culture has changed and so have the challenges associated with it. However, the cost of delaying process transfer remains stubbornly high. As manufacturing scales increase, these soon mount up to hundreds of thousands of dollars, with Matzmorr estimating that for a biologic with $1 billion sales annually, the cost of every month lost during technology transfer is an eye-watering $80 million. With figures like this, it is little wonder that getting scale-up right is what keeps bioprocess scientists awake at night.
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