Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-1.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-1.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-2.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-2.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-3.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-3.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-4.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-4.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-5.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-5.php on line 5

Warning: include_once(/home/aspenxadmin/public_html/files/EIT_html_excerpt.php): failed to open stream: No such file or directory in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-6.php on line 5

Warning: include_once(): Failed opening '/home/aspenxadmin/public_html/files/EIT_html_excerpt.php' for inclusion (include_path='.:/opt/alt/php72/usr/share/pear') in /home/aspenxadmin/public_html/wp-content/themes/magzilla/framework/vc_shortcodes/module-6.php on line 5

Warning: in_array() expects parameter 2 to be array, string given in /home/aspenxadmin/public_html/wp-content/plugins/ajax-search-pro/includes/classes/actions/class-asp-indextable.php on line 156

Warning: get_class() expects parameter 1 to be object, null given in /home/aspenxadmin/public_html/wp-content/plugins/real-media-library/inc/comp/WPML.class.php on line 32
Engineering Challenges in Therapeutic Protein Product and Process Design | Aspen Xchange
Warning: Use of undefined constant full - assumed 'full' (this will throw an Error in a future version of PHP) in /home/aspenxadmin/public_html/wp-content/themes/magzilla/header.php on line 64


Biologics represent the fastest growing sector of the pharmaceutical industry, yet their manufacture lags significantly behind that of small molecule drugs. This paper discusses the main product-related and process-related challenges during the development and production of therapeutic proteins, with particular focus on product heterogeneity and process monitoring and analytics. Emphasis is placed on novel contributions from the field of computational research that aim to enable the application of model-based process control strategies or are working towards the development of a digital twin of bioprocesses. Lastly, we review promising developments in the paradigm shift from batch to continuous processing. Learn More