A U.S. Patent for “Depth Filters for Disposable Biotechnological Processes” was awarded to Millipore Sigma on September 29th, 2020. The present invention is a process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers… Learn More