A U.S. Patent for “Method of Manufacturing or Differentiating Mammalian Pluripotent Stem Cells or Progenitor Cells Using a Hollow Fiber Bioreactor” was awarded to StemoniX on September 1st, 2020. The present invention provides a method of manufacturing and differentiating mammalian stem cells, and in one embodiment human induced pluripotent stem cells (iPSc), e.g., manufacturing neuron progenitors, e.g., derived from iPSC, on a large scale by the use of an automated hollow fiber reactor system. In one embodiment, human iPSc that can be differentiated into cardiomyocytes or neuron progenitors are provided. Learn More