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Estimation of Volumetric Mass Transfer Coefficient (kLa)-Review of Classical Approaches and Contribution of a Novel Methodology | Aspen Xchange
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Estimation of Volumetric Mass Transfer Coefficient (kLa)-Review of Classical Approaches and Contribution of a Novel Methodology



The volumetric mass transfer coefficient, usually denoted by kLa, is an important parameter for both the design, scale-up and monitoring of aerated bioreactors. Significant research efforts have been expended over the last decades in order to develop reliable and easy to apply methodologies for determining kLa using aeration experiment and fast oxygen (polarographic) probes. These methodologies have been reviewed in this study followed by the presentation of a new and promising methodology for kLa determination, which can be used when data from step experiments are not available… Learn More