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Online Biomass Capacitance Monitoring During Large Scale Production of Polypeptides of Interest | Aspen Xchange
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A U.S. Patent Application for “Online Biomass Capacitance Monitoring During Large Scale Production of Polypeptides of Interest” was published by Bristol Myers Squibb on August 13th, 2020. The present invention relates to the use of online biomass capacitance monitoring in perfusion cultures as a way to minimize volumes of cell culture media in large-scale manufacturing. In certain embodiments, a biomass capacitance probe is used to measure the viable cell density, and the viable cell density is used in conjunction with a pre-determined constant cell-specific perfusion rate to identify a target perfusion rate. Learn More