New Maps of Chemical Marks on DNA Pinpoint Regions Relevant to Many Developmental Diseases

In research that aims to illuminate the causes of human developmental disorders, Salk scientists have generated 168 new maps of chemical marks on strands of DNA, called methylation, in developing mice. The data, published this week in a special edition of Nature devoted to the ENCODE Project, can help narrow down regions of the human genome that play roles in diseases such as schizophrenia and Rett Syndrome. In the new work, researchers used experimental technologies and computational algorithms that they previously developed to study the DNA methylation patterns of cells in samples of a dozen types of tissues from mice over eight developmental stages. Learn More