A U.S. Patent Application for “Vaccine Compositions Having Improved Stability and Immunogenicity” was published by Novavax on April 2nd, 2020. The present invention is a method of stimulating an immune response in a subject comprising administering a vaccine composition comprising: (i) a nanoparticle comprising a non-ionic detergent core and a viral glycoprotein, wherein the viral glycoprotein is associated with the core; wherein the non-ionic detergent is PS80; wherein the viral glycoprotein is an RSV F glycoprotein and the molar ratio of PS80 to viral glycoprotein is about 30:1 to about 60:1; and (ii) a pharmaceutically acceptable buffer. Learn More