A U.S. Patent for “Compositions for Cell Culture and Methods of Using the Same” was awarded to Bristol Myers Squibb on March 17th, 2020. The present invention is a cell culture process for the production of protein, comprising: a) culturing Chinese Hamster Ovary (CHO) cells which produce a protein of interest in cell culture under conditions that allow for protein production; and b) adding one or more antioxidant selected from the group consisting of catechin, chlorogenic acid, pelargonidin, quercetin, resveratrol, rosmarinic acid and silibinin to the cell culture, wherein protein titer is increased compared to the same cell culture without the antioxidant supplementation. Learn More