A U.S. Patent for “Capture Purification Processes for Proteins Expressed in a Non-Mammalian System” was awarded to Amgen on March 3rd, 2020. The present invention are methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of purifying proteins expressed in non-mammalian expression systems in a non-native limited solubility form directly from a refold solution are also disclosed. Resin regeneration methods are also provided. Learn More