Development of Small-Scale Models to Understand the Impact of Continuous Downstream Bioprocessing on Integrated Virus Filtration

Biotechnology manufacturing has gradually evolved over the years from traditional batch mode operation to more continuous modes of operation with the implementation of continuous perfusion cell culture. Recently, with technical advancements in continuous chromatography and an increased focus on single-use systems, focus has shifted to an integrated upstream and downstream continuous process. However, due to technical constraints and lack of small-scale models, most theoretical continuous manufacturing designs focus on a hybrid continuous system with one or more dedicated virus removal / inactivation steps remaining in batch mode via traditional hold tanks (e.g., low pH inactivation) or as a dedicated offline step (e.g., virus filtration). Learn More