A U.S. Patent for “Tangential Flow Depth Filtration Systems and Methods of Filtration Using Same” was awarded to Repligen on January 21st, 2020. The present invention is a bioprocessing system comprising: a bioreactor; a tangential flow depth filtration (TFDF) unit comprising a melt-blown thick-walled hollow fiber formed from at least one polymer and comprising a porous wall having a pore size and a density, the porous wall defining a lumen that is in fluid communication with the bioreactor; a permeate fluid outlet in fluid communication with the porous wall; and a pump in fluid communication with the lumen; wherein the density is between 51% and 56% of the density of an equivalent solid volume of the polymer. Learn More