Chromatography Column Qualification in Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions



A U.S. Patent Application for “Chromatography Column Qualification in Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions” was published by Janssen Biotech on October 24th, 2019. The present invention is a method of operating a chromatography column is described for use in methods of manufacture for producing anti-IL-12/IL-23p40 antibodies, e.g., the anti-IL-12/IL-23p40 antibody STELARA.RTM. (ustekinumab). This method involves collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during operation of the chromatography column… Learn More