A U.S. Patent for “Rupture Disks for Bioreactors and Methods of Using Same” was awarded to Lonza on October 8th, 2019. The present invention is a rupture disk that includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. Learn More