A U.S. Patent Application for a “Signal Polypeptide for Improved Secretion of Protein” was published by MedImmune on September 5th, 2019. The present invention relates to a signal polypeptide for improving excretory production of a heterologous polypeptide, proteins comprising the signal polypeptide, nucleic acids encoding the signal polypeptide, and methods of producing thereof. Exemplary embodiments include an improved signal polypeptide attached to alpha toxin, and methods to produce and isolate alpha toxin. Learn More