A U.S. Patent Application for ” Automated Control of Cell Culture Using Raman Spectroscopy”  was published by Lonza on May 16th, 2019. The present invention provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different cell lines producing different mAbs. Developed predictive models, qualified using an independent cell line not used in calibration… Learn More