An Ultra Scale-Down Method to Investigate Monoclonal Antibody Processing During Tangential Flow Filtration Using Ultrafiltration Membranes

The availability of material for experimental studies is a key constraint in the development of full-scale bioprocesses. This is especially true for the later stages in a bioprocess sequence such as purification and formulation, where the product is at a relatively high concentration and traditional scale-down models can require significant volumes. Using a combination of critical flow regime analysis, bioprocess modeling, and experimentation, ultra scale-down (USD) methods can yield bioprocess information using only milliliter quantities before embarking on highly demanding full-scale studies. Learn More