Improving Reliability of Raman Spectroscopy for mAb Production by Upstream Processes During Bioprocess Development Stages

The use of Raman in Bioprocess development has shown great potential for process understanding and monitoring although there are still some challenges and limitations in performance when conditions such as clone, media or scale are changed during bioprocess development. This study proposes different strategies to balance the different information content of multiple mammalian cell cultivations produced during a bioprocess development program when several conditions are investigated. The aim is to serve as a blueprint to how can PAT approaches be best developed in parallel to bioprocess development. Learn More