Project Alert

Turkish pharmaceuticals manufacturer Pharmactivecplans to establish a biotechnological pharmaceutical factory in Turkey following the clinical trial results of five biotechnological drugs it is developing in partnership with South Korean firm Polus. Pharmactive Technical Operations General Manager Fatih Elay said in a report published by Turkish daily Dünya that the production process of five biotech drugs, which they developed jointly with Polus, was completed, and clinical trials were initiated. He said that if the results came back positive from those trials, they will make the factory investment in Turkey and build a factory that mirrors the one they currently have in Incheon.
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IQHQ, a biotech-focused real estate investment group, acquired the bulk of the development site known as Manchester Pacific Gateway for $230 million, according to public records. The purchase price, which was not disclosed at the time of the late September transaction, underscores the scope of the biotech office developer’s ambitions, which is to remake its new waterfront holdings into a $1.5 billion life science city known as the San Diego Research and Development District, or RaDD. IQHQ was started a year ago by esteemed life science builder Alan Gold, who founded BioMed Realty Trust and sold it to Blackstone Group in a transaction valued at $8 billion. The firm’s focus is on creating unrivaled life science centers in four markets: San Diego, San Francisco, Boston and the United Kingdom. The San Diego endeavor has been characterized as an industry-leading bet on major biotech businesses eventual interest in the downtown market.
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Holiferm has announced plans to establish a pilot plant at the Sci-Tech Daresbury campus in Halton, UK. This comes after the local government in Liverpool awarded a $528,000 grant. The plan is to conduct a proof of concept with the pilot plant which would lead to a full commercial manufacturing site in Wirral. 
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BioAgilytix has made public plans to invest $61 million to expand their site in Durham, North Carolina. The decision comes after the company had considered expanding in Massachusetts but were awarded financial incentives by state and local government. The expansion is expected to create hundreds of new jobs at the site.
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Ginkgo Bioworks has signed a 38,759-square-foot life sciences lease at 10 Wilson Road in the Cambridge area of Boston. The new space is located within The Quad, a four-building, 510,000-square-foot campus that is being developed in phases by The Davis Companies.
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After establishing a manufacturing foothold in Belgium as part of a $315 million deal earlier this year, Catalent is now picking up an adjacent site to add to its booming portfolio. Catalent has acquired a 31,000-square-foot cell and gene therapy facility in Gosselies, Belgium, from Bone Therapeutics' Skeletal Cell Therapy Support SA subsidiary to add to its growing "center of excellence" in the area. Once the $14 million buyout closes in November, Catalent will continue to produce Bone's investigational cell therapy Allob on-site, and Catalent will add the employees there to its workforce. The facility houses quality control and development labs, warehouse space, grade C and B cleanrooms and "equipment as well as land for further development," Catalent said.
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Qilu Pharmaceutical Co. has again selected ABEC to rapidly expand production capacity at their cGMP manufacturing facility in Jinan, Shandong, China. ABEC is delivering several sets of large-scale, stainless-steel, cell-culture bioreactors. To support a robust monoclonal antibody product pipeline, Qilu currently operates the largest total bioreactor capacity in China, and this expansion builds on that leadership. The new bioreactor trains will be installed at Qilu’s Biopharmaceutical Industrial Park, which is one of the largest biopharmaceutical industrial parks in China. Since 2009, Qilu has continuously chosen to partner with ABEC based on excellent process performance, consistent adherence to schedule, and long-term service and support. Learn More

Translate Bio, a clinical-stage messenger RNA (mRNA) therapeutics company, has signed a 10 year lease on 138,000 square feet at 200 West Street in Waltham, Massachusetts. The site, currently being redeveloped by BXP into lab space, is expected to be completed in 2021. 200 West Street features a variety of modern lab spaces, including cold rooms and pilot labs, as well as chemistry and biology labs. The redevelopment site also features an additional roughly 130,000 square feet of developable life science space. With this deal Translate Bio joins a growing list of leading biotech’s that call Waltham home. Learn More

New England Biolabs® (NEB®) has selected ABEC to expand production capacity at their manufacturing facilities in Ipswich and Rowley, MA. NEB, an international leader in the discovery and production of recombinant proteins for molecular biology applications, will utilize multiple customized stainless-steel fermenters for high-density Escherichia coli fermentation. With expected delivery of the ABEC 400L and 1000L fermenters by mid-2021, the expansion will enable NEB to continue to increase their product offerings. ABEC’s extensive experience, complete in-house capabilities, and long-term credibility will ensure NEB’s ongoing ability to manufacture high-quality products with proven lot-to-lot consistency. Learn More

Ultragenyx Pharmaceuticals has announced that it plans to build a new large-scale gene therapy manufacturing facility in Bedford, Massachusetts. The planned Phase I facility will encompass 100,000 square feet and provide important internal capacity to develop and manufacture supply of Ultragenyx’s gene therapies for both clinical stage and approved products. The facility will be able to support two independent manufacturing suites with a capacity of 30 runs per year. Construction of the new facility has begun and is expected to be complete in 2023. Ultragenyx already controls land and development rights for an additional 86,000 square feet of Phase II expansion on-site which could be used to double capacity if needed. Learn More

Lonza has inaugurated the first of two manufacturing suites for antibody-drug conjugate (ADC) drug-linker (payload) manufacturing at the Visp, Switzerland site. This first manufacturing suite handles compounds with occupational exposure levels down to 1ng/m3 and is dedicated to the manufacturing platform for ADC drug linkers. This expansion underlines the strategic position of ADCs in the Lonza portfolio, with the company developing and producing all components of these increasingly important cancer treatments: cytotoxic payloads, antibodies and the required linkers on one site. Learn More

Revance plans to lease a 79,000 square-foot single-tenant building on Campus Drive in Marlborough, Massachusetts. The new site would be home to both aseptic filling and R&D operations. Estimates have the initial capital investment at upwards of $115 million. Revance Therapeutics will create and maintain 76 permanent, full-time jobs at the site. The company has been in talks with city leaders about opening a facility for the past few months. It is understood that the last remaining hurdle is a 15-year tax increment financing deal which is expected to be approved in the coming weeks. Learn More

Pfizer is set to invest roughly $350 million in its three Irish manufacturing sites in Ringaskiddy, Dublin and Kildare. The investment will provide additional manufacturing and laboratory capacity, creating 300 roles over the next two to three years. The roles being created comprise a wide array of highly skilled positions such as engineers, scientists, technicians, and chemists. Part of this investment will allow the construction of a site at Ringaskiddy to manufacture pharmaceutical compounds for the company’s clinical trials across the globe. It will also mark the shift from manufacturing to support the earlier phases of medicine development. Learn More

Sai Life Sciences, one of India's fastest growing CRDMO's, unveiled plans to significantly expand its biology capabilities at its integrated R&D campus in Hyderabad, India with a dedicated 75,000 square foot facility and an augmented team of 170 biologists. The new facility will house expanded in vitro and in vivo biology services, DMPK and toxicology capabilities with the first set of labs scheduled to open in March 2021. Learn More

Aphena Pharma Solutions has completed its $7 million facility expansion and renovation in Easton, MD. The newly renovated, 30,000-sq.-ft. facility and three large blending suites are open for new pharmaceutical business supporting liquids, creams, gels and suspensions. Housed in the new blending suites are two new Feldmeier 1,000-gallon mixing tanks and a sister 100-gallon tank, which offer center agitation mixing and dual alternate directional side sweeps for scale-up and registration batches. In addition, the tanks are jacketed for heat and chilling and are pressurized for powder mixing. Learn More

Sartorius is expanding its presence in Massachusetts with a North American Customer Interaction Center. Sartorius will be opening first units of the new 40,000-square-foot Customer Interaction Center in Marlborough in early 2021. "With our new site in Marlborough, we will be optimizing factory acceptance testing and commissioning of new bioprocess equipment supplied to the North American market. This investment will translate into tangible benefits for our customers, employees, suppliers, and the local community," said the President of Sartorius North America, Mary Lavin. Learn More

Sartorius is expanding its presence in Massachusetts with a North American Customer Interaction Center. Sartorius will be opening first units of the new 40,000-square-foot Customer Interaction Center in Marlborough in early 2021. "With our new site in Marlborough, we will be optimizing factory acceptance testing and commissioning of new bioprocess equipment supplied to the North American market. This investment will translate into tangible benefits for our customers, employees, suppliers, and the local community," said the President of Sartorius North America, Mary Lavin. Learn More

ABEC has announced that it will be providing CSR single-use mammalian cell culture and microbial fermentation systems, including the industry's first 6,000L single-use bioreactor, to BioInno Bioscience's new contract development and manufacturing facility in Suzhou, Jiangsu, China. The facility is expected to be operational by mid-2021. BioInno's facility will utilize single-use technologies to enable multi-product flexibility and rapid time to market, and ABEC's CSR systems will also be used for plasmid DNA and viral vector manufacturing. Learn More

WuXi Biologics has announced the opening of a new process development and testing lab in King of Prussia, Pennsylvania. WuXi Biologics partnered with Discovery Labs and Integrated Project Services (IPS) to lease and renovate the 33,000-square-foot facility, which will include a development lab and shipping, delivery and storage space. The company has already hired more than 50 highly skilled employees to work at the facility, with plans to hire at least 50 more in the coming months. The King of Prussia site is the first of three WuXi Biologics facilities being opened in the United States. Learn More

The City of Vacaville, California has signaled the start of the next generation of development of its world class biomanufacturing cluster by announcing plans to expand it on approximately 300 acres adjacent to existing facilities and to name the entire zone the California Biomanufacturing Center. At the same time, the city announced the creation of the California Biomanufacturing Center, Inc., a nonprofit that will accelerate the growth of the sector in Vacaville by working with industry and academic partners to ensure Vacaville remains a place for biomanufacturing to flourish and to ensure that the industry and community thrive together. Learn More

A startup formed this past summer plans to spend $60 million to build a 60,000-square-foot facility in Fishers, Indiana, as it prepares to offer contract development and manufacturing services to the biopharmaceutical industry. Incog BioPharma Services intends to break ground on the new facility and headquarters as early as December and become fully operational in the first half of 2022. The company will focus its efforts on sterile injectible drugs, which have run into manufacturing issues and shortages in recent years. The company plans to begin hiring early next year and expects to have a workforce of more than 65 within the next two years, ramping up to 150 by the end of 2024. Learn More

AbSci has raised $65 million in equity, proceeds from which will be used to increase production capacity, expand AbSci's facility and support research and development, the company said in its announcement. AbSci's protein printing technology expedites the biopharmaceutical discovery and development process. The news comes about 10 months after AbSci raised a $10.4 million round and $5 million in debt. The company had doubled its space in downtown Vancouver and installed new equipment. AbSci's current raise is the largest by a Portland-area biotech company this year. Learn More

Thermo Fisher Scientific has announced plans to build a $130 million sterile filling plant in Singapore, extending its capacity to develop and manufacture therapies and vaccines to the Asia-Pacific region. The plant, when operational in 2022, will have the capacity to make up to 30 million sterile doses a month and employ more than 300 people. Thermo Fisher said the new plant will initially include a high-speed sterile line approved for live virus filling, followed by an additional line for standard fill/finish. The facility will also have cleanroom capacity, labs, warehousing and offices to support production, the company said. Learn More

UCB has signed an agreement to acquire a new 47-acre campus for its UK operations. The acquisition of the site in Windlesham, Surrey, formerly Eli Lilly's second largest research site in the world, is anticipated to be completed in November 2020. The site will undergo state-of-the-art refurbishment prior to UCB relocating from its current UK headquarters in Slough, Berkshire. UCB's projected investment in the UK, including this site, will be roughly $1.3 billion over five years and the transition to this new facility will support more than 650 high-value jobs in scientific research, translational medicine, clinical development, early manufacturing and commercial roles. Learn More

Merck, known as MSD outside the United States and Canada, this week announced it will construct a new manufacturing facility to significantly expand its production capacity for TICE® BCG, a medicine for the treatment of certain forms of bladder cancer. Once this new facility is fully operational, which could take upwards of 5 years, it will triple current manufacturing capacity. The new facility will be part of the existing Maurice R. Hilleman Center for Vaccine Manufacturing in Durham, North Carolina. While no word yet on the size or cost of the new facility, it is expected to create about 100 new jobs locally. Learn More

In May, NewAge Industries, the parent company of AdvantaPure, bought two of three units in a building within seven miles of its headquarters. NewAge recently purchased the remaining unit and now owns the entire seven-acre property consisting of over 90,000 sq. ft. of future production, warehouse and office space. NewAge recently started Phase 1 of renovations and is preparing areas for clean room manufacturing and offices for production and quality department personnel. The company will use the facility as an additional site for the manufacture of AdvantaSil® silicone tubing and braid reinforced hose, weldable and sealable AdvantaFlex® thermoplastic elastomer (TPE) tubing, and Single-Use molded tubing assemblies. Learn More

NeuBase Therapeutics has signed a 10-year lease for lab and office space at the Pittsburgh Tech Center. The site, part of the New Riviera project being developed by Burns Scalo is a high-end office project on the banks of the Monongahela river in Pittsburgh, Pennsylvania. As of this writing, NeuBase is planning to take occupancy of its new headquarters in March of 2021. No word yet on just how much of the 160,000 sq. ft. office building NeuBase has leased. It is known that other tenants include BlueSphere Bio and the Hillman Cancer Center. Learn More

Forge Biologics has secured $40 million to expand AAV manufacturing CDMO capabilities in 2020, with cGMP production capacity available by mid-2021, and for the development of a novel gene therapy pipeline. Forge Biologics is a viral vector CDMO and therapeutics developer, located in a 175,000 sq. ft. facility in Columbus, Ohio. This facility, referred to as The Hearth, is home to a custom-designed cGMP facility dedicated to AAV viral vector manufacturing, currently capable of up to 50L scale research and toxicology grade AAV manufacturing. By mid-2021, The Hearth will host end-to-end cGMP AAV manufacturing services at 500L scale, enabling biotech and pharma clients the ability to accelerate their gene therapy programs from pre-clinical development through clinical and commercial stage manufacturing. Learn More

Abzena has invested $60 million into a new facility for late phase and commercial cGMP manufacturing. The new roughly 50,000 sq ft 'Lusk' facility, at the company's site in San Diego, CA, houses a process development laboratory and two new cGMP manufacturing cleanrooms for 500L and 2,000L scale in Sartorius single use bioreactors. The facility also houses a GMP warehouse, and analytical development and quality control (QC) laboratories. The new 7,400 sq ft process development laboratory uses Sartorius single-use technology (SUT) bioreactors from Ambr® 250mL to 2L, 50L and 200L STR bioreactor to screen important process parameters to develop robust scaleable processes and ensure seamless manufacturability. Learn More

Investment group Bridgewest has bought the Adelaide biologics manufacturing plant operated by Pfizer and will develop it into a contract drug and vaccine manufacturer. Pfizer, which operates four Australian factories employing 1,000, sold the Thebarton plant for an undisclosed sum to the tightly-held investment group which founded the BioDuro drug manufacturing operations in the United States and China. The Adelaide facility has product development, commercialisation and manufacturing capability in microbial-based products such as proteins, vaccines, and plasmids. It will continue to be operated by Pfizer subsidiary Hospira Adelaide until the third quarter of 2021, when Bridgewest will take control. Learn More

FUJIFILM Corporation has announced that it is expanding its gene therapy offering with the addition of viral vector process development and GMP manufacturing services at FUJIFILM Diosynth Biotechnologies in Tees Valley. The laboratories will be outfitted with state-of-the-art equipment to support upstream (suspension and adherent) processes, downstream processing and analytical development. The viral vector process development laboratories in the UK will be online from spring 2021 with the GMP manufacturing capabilities expected to be available in the Fall of 2021 and will support bulk drug substance production of investigational drugs used in early-stage clinical trials. Learn More

Firmenich has announced the opening of its new biotechnology and naturals pilot plant and laboratory that is Integrated into the Group's flagship ingredients production site at La Plaine, Geneva, Switzerland. "With our new biotechnology pilot plant closely connected with the ingredients production site, Firmenich provides integrated biotech development all the way down to the finished product, without any gaps," said Genevieve Berger, Chief Research Officer, Firmenich. Harnessing digital technology for increased automation, the pilot plant is able to move from single to continuous batch process, increasing efficiency, speed and reducing the use of raw materials. Learn More

A biotech company that is involved in the federal government's initiative to develop and distribute a COVID-19 vaccine next year might move into a building in Gaithersburg. City officials won't disclose the name of the company, but Assistant City Manager Tom Lonergan told Bethesda Beat that it is involved in Operation Warp Speed - a partnership between federal government agencies to produce more than 300 million doses of the vaccine. The building, at 700 Quince Orchard Road, is in an area of Gaithersburg near multiple biotech companies and adjacent to the National Institute of Standards and Technology campus. Learn More

Adaptive Biotech has celebrated the topping off of its new 100,000 sq. ft. facility being constructed in Seattle, Washington. The site, located at 1165 Eastlake Ave E, is roughly a six-minute walk from the company's current location at 1551 Eastlake Ave which the company plans to retain. Construction of the new building is on schedule to be completed in the latter part of 2021. Adaptive, which spun out of the Fred Hutchinson Cancer Research Center, works closely with Microsoft as part of its long-term quest to diagnose multiple diseases from a single blood test. Learn More

ABEC has announced it is supporting Serum Institute of India by delivering six 4,000L CSR bioreactors for the manufacturing of Novavax' COVID-19 vaccine candidate, NVX CoV2373. Serum Institute, the world's largest vaccine manufacturer by number of doses, will utilize ABEC's single-use technologies to advance a global supply of NVX CoV2373 throughout India and low- and middle-income countries. Serum Institute's new facility will be the largest single-use bioreactor-based vaccine manufacturing line in the world.  ABEC's 4,000L CSR single-use bioreactors are the largest in the industry by a factor of two, allowing Serum Institute to double productivity per unit floorspace and achieve the lowest possible cost per dose. Learn More

IQHQ has purchased more than 8 acres of waterfront land to create a life science city along San Diego's Bay. The transaction paves the way for what IQHQ is calling the San Diego Research and Development District, or RaDD, as a massive lab-filled campus where ground-floor retail and unrivaled bay views work to recruit the biggest names in the biopharma industry. IQHQ plans to begin construction on site infrastructure immediately with a stated goal of completing the first phase of the district by the summer of 2023. The overall project, estimated to cost $1.5+ billion includes a series of mid-rise structures and one 17-story tower, as well as a museum, and 3 acres of green space and rooftop decks. Learn More

Catalent has acquired a new manufacturing facility in Bloomington, IN, to create a North American center of excellence for early-phase clinical biologics formulation development and drug product fill/finish services. The $14 million investment includes the acquisition, build-out, and qualification of the 23,000 sq. ft. facility to begin supporting customer programs starting January 2021. The facility, purchased from AB BioTechnologies, will be fully integrated with Catalent Biologics' main Bloomington facility located nearby, where the company recently announced a $50 million investment to install an additional high-speed vial filling line. Learn More

Volastra Therapeutics, a biotech company that works in the development of cancer treatments, has signed a lease for 11,000 sq. ft. of lab space in NYC. The specialized space, located in the Mink Building at West 126thSt. and 1361 Amsterdam Ave, includes a chemical fume hood, vacuum system and autoclave pressure chamber. The lease is structured with the potential for easy expansion and term extension, according to Scott Metzner, principal of Janus Property, which has redevelopment The Mink Building as part of its 1.1 million square feet master planned Manhattanville Factory District. Learn More

Webster developer Galaxy Life Sciences has plans to build a $50-million facility in the Worcester biomanufacturing campus The Reactory, offering the site its second planned building. While Galaxy plans to build this facility without having a tenant lined up Galaxy principal Michael O'Brien and Vice President Matthew Zicaro believe the Massachusetts life sciences industry is so strong, they will have a new tenant lined up in a matter of months. If all goes according to plan, Galaxy can then use this development to build out the rest of the 46-acre Reactory site, creating a biotech cluster in Worcester. Learn More

Breakthrough Properties has announced the lease of the property at 105 W. First St. in Boston, Mass. to CRISPR Therapeutics, a gene editing company. CRISPR will fully occupy the building, dubbed "The 105," which totals 263,500 square feet of office and lab space. Construction of the building began in 2020 and the property is scheduled for delivery in early 2022. It was designed by architecture firm Payette as a best-in-class laboratory building. Currently, CRISPR has R&D facilities in Cambridge, MA as well as offices in San Francisco, CA. No word yet if the company plans to consolidate its operations at the new site. Learn More

Kicking a football through a ceremonial goalpost, Lou Kassa joined with founders and county officials to celebrate the launch of a $19 million expansion of the Pennsylvania Biotechnology Center, a long-awaited project that is expected to bring more than 100 new jobs to the facility after its planned fall 2021 opening. "We've been at full capacity for the past seven years and we have a waiting list of companies that want to locate in the PABC," said Kassa, executive vice president of the PABC and the Blumberg Institute, which manages the center. "At the same time, there will be opportunities for new companies to move into the PABC with our expansion." Learn More

BioNTech is buying a production site for the COVID-19 vaccine it is developing with Pfizer, aiming to boost output by several hundred million doses next year, and hopes to have the shot ready to file for approval in October. It is buying the facility, in the German city of Marburg, from Swiss drugs giant Novartis. The facility will be converted to be fully on stream in the first half of 2021 with an annual production capacity up to 750 million doses of the inoculation. The transaction with Novartis, for which the price tag was not disclosed, is part of a push to prepare for a global roll-out of the pair's experimental vaccine, based on so-called messenger RNA (mRNA) technology. Learn More

Aphena Pharma Solutions, a service provider in the pharmaceutical and biological industries, has announced plans to invest $21 million to expand, renovate and retrofit its operations in Cookeville, Tennessee. The 500,000 sq. ft. renovated facility enable the consolidation of two other sites while enabling growth in biologic packaging, cold chain storage and 3PL distribution services. The project is expected to created 160 new jobs over the next five year. Learn More

Takeda has announced the expansion of its cell therapy manufacturing capabilities with the opening of a new 24,000 square-foot R&D cell therapy manufacturing facility at its R&D headquarters in Boston, Massachusetts. The R&D cell therapy manufacturing facility will produce cell therapies for clinical evaluation from discovery through pivotal Phase 2b trials. The current Good Manufacturing Practices (cGMP) facility is designed to meet all U.S., E.U. and Japanese regulatory requirements for cell therapy manufacturing to support Takeda clinical trials around the world. Learn More

Bushu Pharmaceuticals, one of Japan's largest CMO's, has unveiled a major capital program costing $100 million to expand its footprint, capacity and portfolio of services over the next five years. These monies will be used to expand inspection capacity to 12 stations for pre-filled syringes, and seven stations each for liquid vials and for lyophilized vials. Of the 26 inspection stations, 23 will be supported by cameras. Additionally, Bushu has also funded the addition of eight new packaging lines, including one pre-filled packaging line and a new water-for-injection line to support its sterile manufacturing filling suite. Bushu is also upgrading its production automation systems and its laboratory information management system (LIMS). Learn More

Beam Therapeutics has announced that it will invest $83 million and hire 201 employees for its new Research Triangle Park manufacturing facility. The investment, which will occur over a five-year period, will further enable the manufacture of precision medicine. "We believe investment in strategic manufacturing capabilities is an important component of fully realizing the power of our base editing technology and achieving our vision to provide life-long cures to patients suffering from serious diseases", said John Evans, CEO of Beam Therapeutics. The company's project is being facilitated by a Job Development Investment Grant. Learn More

Merck KGaA announced this week that it would invest $69.5 million in expanding its manufacturing capabilities, and capacity for high-potent active pharmaceutical ingredients and antibody-drug conjugates at its U.S. facility near Madison, Wisc. The biopharma company said the investment would allow manufacturing of compounds for therapies which have the potential to treat cancer, and it would create roughly 50 full-time jobs starting in 2021. Completion of the expansion, which consists of a roughly 70,000 square foot commercial building, is expected by mid-2022, the company said. Learn More

Catalent is investing $130 million to bolster manufacturing capacity at its gene therapy campus in Maryland. The company said the site in Harmans will add five Phase III to commercial-scale manufacturing suites, bringing the two state-of-the-art facilities to a total of 15 such suites. Catalent said 10 of the suites are expected to be qualified and operational by the first quarter of 2021, now that the first facility has been approved by the FDA for commercial manufacturing. The new building and its five suites are expected to be operational in the first half of 2022. The new building will also offer cold storage warehousing, office space and more. Learn More

In a recent filing with the SEC, Five Prime Therapeutics has made public the decision to sublease its lab and office space at 111 Oyster Point Blvd in South San Francisco, California. The terms of the deal have Sutro Biopharma initially acquiring 85,755 sq. ft. of the site in April, 2021. The remainder of the site, roughly 29,711 sq. ft., would be occupied some 24 months later. According to the filing the sublease will expire in December, 2027. Alert readers will recall that initial rumors of Five Prime's possible need to sublease the site began circulating in the latter part of 2019. Learn More

Bionova Scientific has initiated construction of its new state-of-the-art biologics manufacturing facility. Construction will be completed in approximately 10 months, with commissioning scheduled for Q3 2021. The 36,000 sq. ft. facility will utilize single-use technologies for all core unit operations and is designed to accommodate two 2000L mammalian cell culture trains, capable of producing clinical and commercial bulk drug substance. Located within Bionova's 56,000 sq. ft. headquarters, the plant is optimized for multi-product manufacturing of monoclonal antibodies and other recombinant proteins. Bionova has partnered with industry leaders DGA and Dome Construction for design and construction. Learn More

Novartis has announced that it is constructing a new production unit for experimental drugs on the outskirts of the city of Basel. The roughly $78 million investment will give it two new production lines. Both will be dedicated to producing active ingredients for experimental medicines. The production lines will be developed in an existing building in the Schweizerhalle industrial area on the outskirts of Basel. These new facilities will be commissioned at the end of next year. This investment confirms the importance of Schweizerhalle as a global production site, Novartis said. Learn More

The developer that owns Hilltop Mall has rebranded the 78-acre property as the East Bay Science and Technology Center and plans to sell or lease it, according to published reports. After purchasing the property in 2017, LBG Real Estate Cos. had planned to modernize the shopping center and construct housing, office space and a hotel on the Hilltop drive property. Those plans have since changed, with the COVID-19 pandemic cited as a contributing factor. The mostly vacant mall, about 16 percent occupied by retailers, is "now looking to offload the asset, pitching it as a new potential center for life sciences and biotech space." Learn More

Regeneron has announced plans to expand operations at its site in Limerick, Ireland adding roughly 400 new jobs. The expansion is a result of a decision to prepare Regeneron's plant in New York to produce a potential new antibody-based treatment for Covid-19, REGN-COV2. The new roles will be in a wide variety of areas, including commercial manufacturing, process sciences, quality assurance/control, supply chain and various support functions for scientists, chemists and technicians. Regeneron has been in Limerick since 2014, when it took over the old Dell factory in the city and has since invested over $1 billion in its campus which became operational in 2015. Learn More

Plans have gone out to consultation to build a 10-storey office and research building for US biopharmaceuticals giant Merck opposite King's Cross station in London. Designed by architect AHMM, the MSD Discovery Hub, is expected to achieve a BREEAM Outstanding rating and will have an innovative biophilic façade incorporated as part of the plan for a carbon-efficient building. The low-rise existing Belgrove House on Euston Road will be demolished to make way for the research building, also incorporating a new London Underground station entrance. Learn More

Bristol Myers Squibb has signed a 360,000 square- foot lease at 250 Water Street in Cambridge Crossing, the new and connected neighborhood at the intersection of Cambridge, Somerville, and Boston. The new building is currently under construction and is expected to be complete in late 2022. Bristol Myers Squibb plans to combine its Cambridge presence at the state-of-the-art laboratory and office building by the end of the first half of 2023. The site is a 43 acre parcel being developed to offer 2.1 million sq. ft. of state-of-the-art science and technology space and includes 11 acres of open space. Learn More

AdvanceTEC has announced that the company has been awarded a contract stemming from "Operation Warp Speed" COVID-19 vaccine initiative to provide fast-track cleanroom integration.  As a part of this project, the company is working with one of the top five identified companies for rapid creation and deployment of a vaccine for COVID-19 Coronavirus. Key to delivering the project is AdvanceTEC's "Cleanroom IP" platform, which leverages in-house proprietary algorithmic technology, and harnesses digital field scanning, 3D BIM / VDC modeling, laser field layout, off-site fabrication and JIT on-site integration for a robust concept to commissioning delivery. Learn More

Merck & Co., known in Europe as MSD to ensure no confusion with Merck of Germany, has made public plans to build a $1.3 Billion research hub in London. The site, which is rumored to be planning to be home to 800 people, will cover an area of roughly 270,000 sq. ft. (25,000 m2). According to published reports, the official name of the site will be the London Discovery Research Center with construction planned to commence in the latter part of next year. The schedule calls for Merck to occupy the site in 2025 with many of the early occupants being drawn from other Merck sites in and around London. Learn More

Galaxy Life Sciences has inked a deal to build an estimated $50 million building on a 6-acre plot at The Reactory biomanufacturing park. The deal also grants Galaxy Life Sciences the right to develop the remainder of the available lots in the biomanufacturing park on the former Worcester State Hospital campus. Galaxy Life Sciences bought the 6-acre parcel at The Reactory from the Worcester Business Development Corp., this week for $1.9 million, according to documents filed at the Worcester Registry of Deeds. This fall the WBDC and the city of Worcester will begin to construct and upgrade the roadway network and all necessary utilities to service the sites at The Reactory. Learn More

Samsung Biologics has announced plans to break ground on a fourth manufacturing plant, the 'P4 Super Plant', this year and that it is in negotiations with local officials to purchase additional land for its second bio complex. The total size of the two investments is expected to be roughly $2 billion. Adding 256KL capacity to its site, Plant 4 is scheduled to commence manufacturing activities in the second half of 2022. The land under negotiation for Samsung Biologics' second bio complex measures 330,000 square meters. The company plans to create an Open Innovation center to foster biotech companies and build a global R&D facility in addition to securing space for future plants within the new complex. Learn More

Eisai is the latest firm to call Prism's On3 campus home. The Japanese firm will occupy the iconic 15-story International style tower that anchors the life-science campus straddling the border of the Township of Nutley and City of Clifton in New Jersey. Presently based in Woodcliff Lake NJ, the company will relocate its headquarters and up to 1200 corporate staff and research and development activities to Nutley by the end of 2021. According to Prism, this state-of-the-art building and campus will ultimately bring all of Eisai's New Jersey-based employees together in one place to foster extensive employee engagement and collaboration. Learn More

MeiraGTx has announced plans to significantly expand its manufacturing facility in Shannon, Ireland. The expanded facility will be designed for the manufacture of commercial-grade gene therapies. The facility will cover roughly 90,000 sq. ft. (8,300 sq. meters) in two separate buildings and will be designed to meet global regulatory requirements, including the US FDA. The unit at Shannon will be used for the manufacture of MeiraGTx viral vectors for gene therapies and the plasmid DNA that is one of the starting materials in viral vector production. The plasmid production facility is expected to be operational by the end of 2020, and the second viral vector manufacturing facility to be operational by the end of 2021. Learn More

Sekisui is investing nearly $20 million (£14.4 million) in its biopharma CDMO business aimed at expanding cGMP microbial capacity at the existing site in Maidstone, Kent, UK to be completed by 2022. This investment follows the investment of $1.9 million in its new Bioprocess Innovation Centre, completed in October 2019, and is part of a long-term investment strategy to grow its share of the microbial biopharma CDMO market. The facility expansion and cGMP upgrades will enable Sekisui to take on drug substance contract manufacturing for clinical trials. The new cGMP certified microbial fermentation and purification suites will accommodate production scales up to 1,000L, complementing its existing capabilities which range from 20L to 5,000L fermentation scale. Learn More

Wacker is investing in its production facilities for biologics, LMPs (live microbial products) and vaccines at its Amsterdam site. Projects include the construction of a new fermentation line with a volume of 1,500 liters as well as the setting up of new cleanroom structures in the 270-liter fermentation line. According to the company, the investment price is a mid-double-digit million-euro amount. Among other improvements, new utility supplies are planned, such as water for injection. These measures will contribute to preparing the plant to produce new classes of actives, such as pDNA and mRNA-based vaccines. Learn More

Sandoz plans to spend more than $175 million to develop and outfit its European hub for antibiotics manufacturing in Kundl, Austria with new technology. The investment, which will occur over a five-year period, comes from both Sandoz and the Austrian government and is meant to strengthen Europe's competitive position for manufacturing key antibiotics. For its part, the Austrian government will contribute roughly $60 million which will be earmarked for technology used in the manufacture of the API's associated with penicillin products. Learn More

SCA Pharma, an FDA-registered outsourcing facility, has announced that it will expand its operations in Little Rock, Arkansas. SCA will be investing more than $10 million and will create the opportunity to double its current Little Rock workforce of 180 people.  Additionally, the investment will allow SCA Pharma to renovate an existing 42,000-square-foot facility at the Clinton National Airport and construct an additional 20,000-square-foot facility adjacent to the existing facility. This comes after the announcement by SCA last week that it also plans a 40 percent expansion of its Windsor, Conn. facility. Learn More

MilliporeSigma has announced plans to build a new, $20 million laboratory facility in Buchs, Switzerland to support its rapidly growing reference materials business. Completion of the three-story, 12,000-square-foot Buchs building is scheduled for December 2021 and the move is planned for early 2022. The modern, flexible workplace design, to include laboratory and office space, is aimed at fostering a collaborative environment for its 40 employees, some of whom will move from the existing, heavily utilized building. The new facility will offer a more efficient way of working for current and future employees in research and development, analytical production and quality control. Learn More

Vanqua Bio is expanding its operations in Illinois by leasing space for additional research labs at The Labs in Lincoln Park. The site was recently redeveloped by Sterling Bay and consists of 125,000 sq. ft. of space ideally suited for research labs. Vanqua plans to move into the new space in January 2021. Learn More

AstraZeneca has been granted approval to move forward with the expansion of Building 52 at its Hurdsfield site in Macclesfield, United Kingdom. The resulting two story building will add roughly 95,000 sq. ft. of space in which to house manufacturing, technical storage and preparation. The approval of the project by local authorities has the pre- condition that AstraZeneca must conduct remediation of the site prior to the commencing of construction. Learn More

Kodiak Sciences has embarked on a major expansion with a lease of large office buildings in Palo Alto's choice Stanford Research Park, regulatory documents show. The company has leased about 155,000 square feet from an affiliate of Sand Hill Property Co., documents filed with the Securities and Exchange Commission and state government officials show. The buildings are part of a Sand Hill Property project that has launched a dramatic redevelopment of an old office complex at the corner of Page Mill Road and Hanover Street in Palo Alto. "The company expects to use the buildings as its new corporate headquarters for research laboratories and office space," Kodiak Sciences said in SEC documents that were filed on June 25, 2020. Learn More

Aldevron is building its second GMP manufacturing facility, the latest one to be 189,000 sq. ft. residing on the company's existing 14 acre site in Fargo, North Dakota. The new manufacturing facility is expected to be fully operational by Q1 of 2021. In total, three new buildings are slated to be built over the next three to five years to support the rapidly growing field of genetic medicine. Learn More

RoslinCT has begun construction of the expansion of their new manufacturing center. The new state of the art 17,000 sq. ft. (1,600 m2) facility will operate to US and EU GMP standards and will become an innovative hub for the manufacture of cell and gene therapy products. The new custom-designed facility will encompass five clean rooms, warehousing and offices for all supporting activities and will include a dedicated training lab. Learn More

The Altec Styslinger Genomic Medicine and Data Sciences Facility would encompass 145,000 sq. ft. of lab and office space at the Birmingham campus of the University of Alabama. Earlier this month, the UA System Board passed a Stage III approval, which will allow the design and bidding of the project to proceed-although final Stage IV approval is still required at a future meeting. Current plans would include the renovation and expansion of the Lyons Harrison Research Building at 701 19th Street South. The development would also involve demolishing the adjacent Pittman Center for Advanced Medical Studies Building and the Kracke Building. Learn More

Plans are moving forward for Selkirk Pharma's $30 million manufacturing facility on the West Plains. The company, a CMO, intends to build a 65,000-square-foot manufacturing facility at 9110 W. Granite Ave. in the Pacific Northwest Technology Park, according to an application filed with the city of Spokane. This same application notes that construction is expected to begin in August of this year and is slated for completion in December 2021. Learn More

Plans are moving forward for Selkirk Pharma's $30 million manufacturing facility on the West Plains. The company, a CMO, intends to build a 65,000-square-foot manufacturing facility at 9110 W. Granite Ave. in the Pacific Northwest Technology Park, according to an application filed with the city of Spokane. This same application notes that construction is expected to begin in August of this year and is slated for completion in December 2021. Learn More

Cellular Technology Limited (CTL), a global biotech company has closed on the purchase of the 36,700 sq. ft. Chagrin Corporate Center in Shaker Heights, Ohio. To support the planned expansion the city has proposed amendments to its zoning code to allow not only for expanded uses in office space, but also more flexibility in adding laboratories and research facilities, along with "limited production processing," to what has been a very short list of permitted uses in the city's Office Districts. Learn More

Oxford Biomedica has signed a Collaboration Agreement with the Vaccines Manufacturing and Innovation Centre (VMIC). This five-year Agreement will involve the organizations working collaboratively to enable the manufacture of viral vector based vaccines, contributing towards a rapid increase in UK domestic capacity for this specialized field of vaccine manufacturing. As part of the Collaboration Agreement, VMIC will provide manufacturing equipment for Oxford Biomedica to rapidly equip two new GMP manufacturing suites within Oxford Biomedica's new 7,800 m2 commercial manufacturing center, Oxbox, located in Oxford, UK. Learn More

Fujifilm has made public plans to invest roughly $928 million in the Denmark site of FUJIFILM Diosynth Biotechnologies. The investment will expand production lines for bulk drug substance with the addition of a further six mammalian cell bioreactors, bringing the total to 12 x 20,000-liter bioreactors by fall 2023, making the Denmark facility one of the few major large-scale manufacturing facilities in the bio-CDMO industry. The development will also include the addition of the Denmark site's first fill/finish production line (added by summer 2023), featuring a fully-automated, cutting-edge system capable of producing up to approximately 35 million units per annum to cater to large-scale production. Learn More

WuXi Biologics has announced that it has signed a 10-year lease for a clinical manufacturing facility (MFG18) in Cranbury, New Jersey. The new clinical manufacturing facility will feature a total of 6000 L of bioreactor capacity as well as Process Development (PD) suites, Quality Control (QC) labs, all of which accompanied by supporting functions. The 66,000-square-foot facility is expected to become operational in late 2020 and will bring in up to 100 jobs to the region. This is the third plant for WuXi Biologics in the U.S. joining a previously announced manufacturing site in Worcester, Massachusetts and a PD lab in King of Prussia, Pennsylvania. Learn More

Plans for a new 10-story, 500,000 square-foot bioscience lab and office tower to be built atop the former Route 34 corridor have advanced in New Haven, Connecticut. The tower, to be built at 1010 College Street, is expected to cost upwards of $100 million. Local firm Winstanley Construction is heading up the re-development of the site including construction. Learn More

Biotech firm GRAIL, headquartered in Menlo Park, California, has promised to invest at least $103 million to build a 200,000-square-foot "state-of-the art" laboratory in Durham. It will include an office and warehouse space in North Carolina's Research Triangle Park. GRAIL is a healthcare company whose mission is to detect cancer early. It is using the power of next-generation sequencing, population-scale clinical studies, and computer and data science to enhance the scientific understanding of cancer biology and develop a multi-cancer early detection blood test. Since early 2016, GRAIL has raised more than $1.9 billion in four rounds of equity financing. Learn More

AGC Biologics has announced that it has acquired AstraZeneca's 300,000-square-foot facility in Boulder and will revive manufacturing operations there in April. The Japanese biopharma, which provides contract development and manufacturing services globally, said it will invest $100 million in and employ 280 workers at the facility, located at 5550 Airport Blvd. The Boulder plant houses two 20,000-liter stainless steel mammalian cell bioreactors, and the company noted it could fit up to four more on its 20 acres. Alert readers will recall that AstraZeneca acquired the facility from Amgen in 2015 which had shut it down in 2012. Learn More

POINT Biopharma, a global, clinical-stage pharmaceutical company specializing in the development and production of radiopharmaceuticals for cancer treatments, will establish its first U.S. manufacturing facility in Indianapolis, Indiana. POINT will invest more than $25 million to purchase and transform an existing 77,000-square-foot, food-grade building at 4850 W. 78th St. in Indianapolis into a state-of-the-art, Good Manufacturing Practices facility. The company expects to move into its new space this year and to be fully operational by 2021. Learn More

Takara Bio has bought two buildings totaling 129,000 sq. ft. from the University of California Regents. The company will shift its local headquarters from Mountain View, where it currently is a tenant, to the pair of north San Jose buildings. Takara paid $44.8 million for the two buildings, according to property documents filed with county officials on May 12th. The two properties, located at 2560 and 2570 Orchard Parkway are part of the four-building Valley Research Center, near the corner of Orchard Parkway and West Trimble Road and just down the block from North First Street and its light rail lines. The deal appears to position Takara for a significant expansion. Learn More

Meissner's new manufacturing facility is roughly 42,000 sq. ft. in size and features a state of the art 10,000 sq. ft. class 7 cleanroom dedicated to the manufacture of single-use systems. Validation of the facility was completed in min-April and the facility is currently manufacturing products for their biopharma clients. Anticipating future expansions at the time of purchase, Meissner included adjacent land with initial groundwork for this development set to begin later this year. Learn More

NewAge Industries has closed a deal to buy two building units at a location within seven miles of its southeastern Pennsylvania headquarters. The two building units consist of 46,000 sq. ft. of manufacturing space with an additional 3,000 sq. ft. of offices. The manufacturing area will house tubing extrusion machinery, injection molding presses, clean rooms for high purity product manufacturing and packaging, and quality inspection areas. Quality department personnel and department supervisors will use the office space. NewAge plans to inventory and ship products directly from the new location. Renovations at the new location will begin this summer with additional remodeling extending into next year. Learn More

Life-science real estate firm IQHQ this week announced that it has acquired Innovation Park in Andover with plans to spruce up its amenities. The developer plans to redesign the 200,000 square foot campus on 4 Corporate Drive, adding new amenities such as a cafe and fitness center, which will both have indoor and outdoor spaces. Citing an increasing demand for office and lab space, the company said Innovation Park's newest tenants - the University of Massachusetts Lowell and drug and device development firm Ora Inc. - have signed long-term leases. This is the company's third project in Greater Boston. Learn More

WuXi Biologics and the Worcester Business Development Corporation (WBDC) have announced the successful signing of a land deal for WuXi Biologics' clinical and commercial manufacturing facility (MFG11) in Worcester at The Reactory, a 46-acre master-planned biomanufacturing campus. The approximately 107,000-square-foot, two-story facility will be operational in 2022 and create 150 new jobs. Craig Blais, the president and CEO of the WBDC, stated, "WuXi Biologics' decision to locate its first US biomanufacturing facility in Worcester at The Reactory confirms the value of Worcester's strong life sciences ecosystem. We expect other biotech manufacturers will soon follow their lead." Learn More

Instruments maker Thermo Fisher plans to spend $180 million to build a 290,000-square-foot site that will double capacity to make viral vectors, the inactivated viruses used to convey gene therapies into human cells. The contract development and manufacturing organization plans to complete work on the facility in Plainville, Massachusetts, in 2022 and add more than 200 jobs. Thermo's investment is the latest in a series of expansions designed to meet growing demand for gene therapies and vaccines, the company said in a statement. Learn More

Allakos has committed to 98,133 square feet of pre-lease space at Alexandria Real Estate Equities' The Alexandria District in San Carlos. The biopharma plans to occupy one of two structures under development that total 526,178 square feet. ChemoCentryx previously took 96,000 square feet at the development, with an August move-in date planned. The buildings are within the planned six-building, 1.6-million-square-foot biotech campus near Stanford, and located equidistant between San Francisco and San Jose at 825 Industrial Rd., San Carlos. The company, which has an existing headquarters in Redwood City, plans to take occupancy in the summer of 2021. Learn More

IQHQ, a life sciences real estate development company, will acquire a key development site in South San Francisco to develop into what it hopes will become another premier life science real estate and R&D complex. The two-acre site, currently known as South City Station at 580 Dubuque Avenue, is located in the heart of South San Francisco, one of the West Coast's fastest growing markets for life sciences. The deal is an off-market transaction and is entitled for a 213,000-square foot development. The purchase price was not disclosed. The location is prime as it is immediately adjacent to the new South San Francisco Caltrain Station, which is expected to open in Spring of 2021 and will connect San Jose to Downtown San Francisco. Learn More

The Lonza Biologics facility at Pease International Tradeport is part of a collaborative effort to manufacture a vaccine against the COVID-19 infection. Work at the Portsmouth facility is expected to ramp up in June as biologics for the vaccine are transferred to the plant, according to the company. Alert readers will recall that Moderna announced last week that it is manufacturing a potential COVID-19 vaccine - called mRNA-1273 - in cooperation with Lonza. The vaccine is not yet approved by the U.S. FDA. Having done phase 1 trials in March, the company on April 27 submitted application to the FDA to begin phase 2 trails, with phase 3 trials beginning as soon as fall 2020. Learn More

The New Jersey Innovation Institute (NJII), has launched BioCentriq as its cell and gene therapy production and manufacturing center. BioCentriq is a process development and clinical manufacturing facility for cell and gene therapies located in Newark, NJ. The Biopharma Division has initiated the qualification and validation process for the BioCentriq facility and its equipment. This GMP facility is located at NJIT's Life Sciences and Engineering center and features two GMP suites. The GMP suites are expected to complete their qualification and validation and be operational this summer. BioCentriq also offers a process development center, currently located at the Rutgers Medical School in Newark, which has been supporting projects since late 2019. Learn More

Fujifilm Diosynth has entered into a deal with the Bill Gates funded COVID-19 Therapeutic Accelerator which will devote some of its manufacturing capacity at its Hillerød, Denmark biologics plant for a treatment yet to be identified. The Denmark facility is equipped with six large-scale bioreactors for the manufacture of cell-culture-derived biologics for clinical and commercial use, the company said. The agreement also stipulates Fujifilm will support assembly, labeling and packaging requirements for the to-be-decided pharma partner. The deal sets aside an unspecified production volume for 2021 with options for the following years, Fujifilm said. Learn More

A new biotech research facility in Alachua, Florida has sold for $12 million. According to published reports the facility is one of four scheduled to be developed for Applied Genetic Technologies Corporation (AGTC) which has ongoing operations in the area. The facility, located in Foundation Park, encompasses roughly 43,000 sq. ft. of space and is anticipated to be a sought-after property for biopharma firms in the area looking to expand. In addition to its proximity to AGTC the site is located just across from Progress Park and UF Innovate's Sid Martin Biotechnology Incubator. Learn More

Biopharma ScieGen is expanding its manufacturing operations on Long Island and adding over 100 jobs. The $15 million expansion will help ScieGen, a subsidiary of Bactolac Pharmaceutical, bolster its production of prescription drugs to meet growing demands. The company plans to convert 65,000 s/f of former warehouse space at its facility at 33 Oser Avenue in Hauppauge into manufacturing space with washrooms, an office, labs and a cafeteria. The company says it will use Long Island-based vendors to make the space FDA compliant. Learn More